Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020092207 - BROADLY REACTIVE IMMUNOGENS OF INFLUENZA VIRUS, COMPOSITIONS, AND METHODS OF USE THEREOF

Publication Number WO/2020/092207
Publication Date 07.05.2020
International Application No. PCT/US2019/058296
International Filing Date 28.10.2019
IPC
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
C07H 21/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
C07K 14/005 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Applicants
  • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION [US]/[US]
Inventors
  • ROSS, Ted Milburn
  • CARTER, Donald M.
Agents
  • HUNTER-ENSOR, PH.D., Melissa
Priority Data
62/751,69128.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BROADLY REACTIVE IMMUNOGENS OF INFLUENZA VIRUS, COMPOSITIONS, AND METHODS OF USE THEREOF
(FR) IMMUNOGÈNES LARGEMENT RÉACTIFS DU VIRUS DE LA GRIPPE, COMPOSITIONS, ET MÉTHODES D'UTILISATION ASSOCIÉES
Abstract
(EN)
Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from H1 influenza virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H1 virus following introduction into a subject. Also provided are non-naturally, pan-epitopic occurring influenza virus immunogens, vaccines, virus-like particles (VLPs), subviral particles (SVPs), and compositions comprising the influenza virus antigens, immunogens, VLPs, SVPs, and vaccines of the disclosure. Methods of generating an immune response in a subject by administering the influenza virus antigens, immunogens, vaccines, VLPs, SLPs, or compositions thereof as disclosed here are provided. For example, the antigens and immunogens comprise the hemagglutinin (HA) protein of H1 influenza virus strains.
(FR)
La présente invention concerne des antigènes pan-épitopiques, non naturels, largement réactifs, dérivés du virus de la grippe H1 qui sont immunogènes et déclenchent une réponse immunitaire largement réactive, telle qu'une réponse d'anticorps neutralisants largement réactifs, contre les virus H1 après avoir été introduits chez un sujet. L'invention concerne également des immunogènes du virus de la grippe non naturels, pan-épitopiques, des vaccins, des pseudo-particules virales (VLP), des particules sous-virales (SVP) et des compositions comprenant les antigènes du virus de la grippe, les immunogènes, les VLP, les SVP et les vaccins selon l'invention. L'invention concerne en outre des procédés de génération d'une réponse immunitaire chez un sujet par l'administration des antigènes du virus de la grippe, des immunogènes, des vaccins, des VLP, des SVP ou des compositions associées. Par exemple, les antigènes et les immunogènes comprennent la protéine d'hémagglutinine (HA) de souches du virus de la grippe H1.
Latest bibliographic data on file with the International Bureau