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1. WO2020092202 - HUMANIZED AND STABILIZED FC5 VARIANTS FOR ENHANCEMENT OF BLOOD BRAIN BARRIER TRANSPORT

Publication Number WO/2020/092202
Publication Date 07.05.2020
International Application No. PCT/US2019/058286
International Filing Date 28.10.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 14/4711
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4711Alzheimer's disease; Amyloid plaque core protein
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Applicants
  • BIOGEN MA INC. [US]/[US]
  • NATIONAL RESEARCH COUNCIL OF CANADA [CA]/[CA]
Inventors
  • SMITH, Benjamin A.
  • LEHMANN, Andreas
  • CAMERON, Thomas O.
  • PEPINSKY, R. Blake
  • WEN, Dingyi
  • FARRINGTON, Graham K.
  • RAGHUNATHAN, Gopalan
  • PEDERSON, Nels E.
  • STANIMIROVIC, Danica
  • SULEA, Traian
  • HAQQANI, Arsalan S.
Agents
  • KOIPALLY, Joseph J.
  • BRENNAN, Jack
Priority Data
62/751,96229.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMANIZED AND STABILIZED FC5 VARIANTS FOR ENHANCEMENT OF BLOOD BRAIN BARRIER TRANSPORT
(FR) VARIANTS FC5 HUMANISÉS ET STABILISÉS POUR L'AMÉLIORATION DU TRANSPORT À TRAVERS LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
Abstract
(EN)
Featured are compositions comprising humanized and engineered variants of an antibody variable domain (e.g., FC5), chimeric molecules comprising same, compositions comprising same, and uses thereof.
(FR)
L'invention concerne des compositions comprenant des variants humanisés et modifiés d'un domaine variable d'anticorps (par exemple FC5), des molécules chimériques les comprenant, des compositions les comprenant, et leurs utilisations.
Latest bibliographic data on file with the International Bureau