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1. WO2020092164 - METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING T CELL-DRIVEN DISEASES

Publication Number WO/2020/092164
Publication Date 07.05.2020
International Application No. PCT/US2019/058114
International Filing Date 25.10.2019
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • THE CHILDREN'S MEDICAL CENTER CORPORATION [US]/[US]
Inventors
  • CHOU, Janet S.
  • GEHA, Raif S.
Agents
  • RESNICK, David S.
  • EISENSTEIN, Ronald I.
  • FITZGERALD, Mark J.
  • BENN, Susanna C.
  • BRAICH, Ravinderjit S.
  • CROSBY, David F.
  • HUFF, Shayne Y.
  • PTASHKA, Teresa A.
  • KLING, Nicole D.
Priority Data
62/752,73830.10.2018US
62/775,09904.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING T CELL-DRIVEN DISEASES
(FR) PROCÉDÉS ET COMPOSITIONS POUR TRAITER ET PRÉVENIR DES MALADIES INDUITES PAR LES LYMPHOCYTES T
Abstract
(EN)
Described herein are methods and compositions for treating graft versus host disease. Additionally, described herein are methods and compositions for treating diabetes. Aspects of the invention relates to administering to a subject an agent that inhibits LRRC8A as a monotherapy or in combination with additional therapeutics.
(FR)
L'invention concerne des procédés et des compositions pour le traitement d'une maladie du greffon contre l'hôte. De plus, l'invention concerne des procédés et des compositions pour traiter le diabète. Des aspects de l'invention concernent l'administration à un sujet d'un agent qui inhibe LRRC8A en monothérapie ou en combinaison avec d'autres agents thérapeutiques.
Latest bibliographic data on file with the International Bureau