Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020092102 - 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

Publication Number WO/2020/092102
Publication Date 07.05.2020
International Application No. PCT/US2019/057746
International Filing Date 24.10.2019
IPC
A61K 31/4709 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines containing further heterocyclic rings
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • MSD R&D (CHINA) CO., LTD. [CN]/[CN]
  • ACTON, John, J., III [US]/[US] (US)
  • EGBERTSON, Melissa [US]/[US] (US)
  • GAO, Xiaolei [US]/[US] (US)
  • HARRISON, Scott, T. [US]/[US] (US)
  • HENDERSON, Timothy, J. [US]/[US] (US)
  • LO, Michael Man-Chu [US]/[US] (US)
  • MAZZOLA, Robert, D., Jr. [US]/[US] (US)
  • MENG, Zhaoyang [CN]/[US] (US)
  • MULHEARN, James [US]/[US] (US)
  • RADA, Vanessa, L. [US]/[US] (US)
  • SCHUBERT, Jeffrey, W. [US]/[US] (US)
  • SELYUTIN, Oleg, B. [US]/[US] (US)
  • TELLERS, David, M. [US]/[US] (US)
  • TONG, Ling [CN]/[US] (US)
  • ZHANG, Fengqi [US]/[US] (US)
  • BAO, Jianming [US]/[US] (US)
  • LI, Chunsing [CN]/[CN] (US)
Inventors
  • ACTON, John, J., III
  • EGBERTSON, Melissa
  • GAO, Xiaolei
  • HARRISON, Scott, T.
  • HENDERSON, Timothy, J.
  • LO, Michael Man-Chu
  • MAZZOLA, Robert, D., Jr.
  • MENG, Zhaoyang
  • MULHEARN, James
  • RADA, Vanessa, L.
  • SCHUBERT, Jeffrey, W.
  • SELYUTIN, Oleg, B.
  • TELLERS, David, M.
  • TONG, Ling
  • ZHANG, Fengqi
  • BAO, Jianming
  • LI, Chunsing
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
PCT/CN18/11240329.10.2018CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
(FR) MODULATEURS ALLOSTÉRIQUES 3-(1H-PYRAZOL-4-YL)PYRIDINE DU RÉCEPTEUR MUSCARINIQUE M4 DE L'ACÉTYLCHOLINE
Abstract
(EN)
The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
(FR)
La présente invention concerne des composés pyrazol-4-yl-pyridine de cinnolinyle et quinolinyle qui sont des modulateurs allostériques du récepteur muscarinique M4 de l'acétylcholine. La présente invention concerne également des utilisations des composés décrits dans le traitement ou la prévention à titre potentiel des troubles et maladies neurologiques et psychiatriques dans lesquels les récepteurs muscariniques M4 de l'acétylcholine sont impliqués. La présente invention concerne également des compositions comprenant ces composés. La présente invention concerne également des utilisations de ces compositions dans la prévention ou le traitement potentiels de telles maladies dans lesquelles sont impliqués les récepteurs muscariniques M4 de l'acétylcholine.
Latest bibliographic data on file with the International Bureau