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1. WO2020091999 - POLYNUCLEOTIDE ENCAPSULATION AND PRESERVATION USING SELF-ASSEMBLING MEMBRANES

Publication Number WO/2020/091999
Publication Date 07.05.2020
International Application No. PCT/US2019/056417
International Filing Date 16.10.2019
IPC
B01J 13/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
B01J 13/10 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
06by phase separation
10Complex coacervation, i.e. interaction of oppositely charged particles
B01J 13/22 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
20After-treatment of capsule walls, e.g. hardening
22Coating
CPC
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 47/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/183
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
183Amino acids, e.g. glycine, EDTA or aspartame
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/62
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
Applicants
  • MICROSOFT TECHNOLOGY LICENSING, LLC [US]/[US]
Inventors
  • STRAUSS, Karin
  • NGUYEN, Bichlien Hoang
Agents
  • MINHAS, Sandip S.
  • ADJEMIAN, Monica
  • BARKER, Doug
  • CHATTERJEE, Aaron C.
  • CHEN, Wei-Chen Nicholas
  • CHOI, Daniel
  • CHURNA, Timothy
  • DINH, Phong
  • EVANS, Patrick
  • GABRYJELSKI, Henry
  • GOLDSMITH, Micah P.
  • GUPTA, Anand
  • HINOJOSA-SMITH, Brianna L.
  • HWANG, William C.
  • JARDINE, John S.
  • LEE, Sunah
  • LEMMON, Marcus
  • MARQUIS, Thomas
  • MEYERS, Jessica
  • ROPER, Brandon
  • SPELLMAN, Steven
  • SULLIVAN, Kevin
  • SWAIN, Cassandra T.
  • TABOR, Ben
  • WALKER, Matt
  • WIGHT, Stephen A.
  • WISDOM, Gregg
  • WONG, Ellen
  • WONG, Thomas S.
  • ZHANG, Hannah
  • TRAN, Kimberly
Priority Data
16/177,18831.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYNUCLEOTIDE ENCAPSULATION AND PRESERVATION USING SELF-ASSEMBLING MEMBRANES
(FR) ENCAPSULATION ET CONSERVATION DE POLYNUCLÉOTIDES À L'AIDE DE MEMBRANES À AUTO-ASSEMBLAGE
Abstract
(EN)
Polynucleotides such as DNA are stored inside vesicles formed from self-assembling membranes. The vesicles may be protocells, liposome, micelles, colloidosomes, proteinosomes, or coacervates. The vesicles may include surface functionalization to improve polynucleotide encapsulation and/or to bind polynucleotides having specific sequences. Encapsulation in vesicles provides protection for the polynucleotides. Additional protection is provided by addition of one or more stabilizers. The stabilizer may be nucleic-acid stabilizers that stabilize the polynucleotides or may be a protective structural layer around the vesicles such as a layer of silica. A process for stably storing polynucleotides in vesicles and a process for recovering stored polynucleotides from vesicles are both disclosed. The polynucleotides may be used for storage of digital information.
(FR)
Des polynucléotides tels que l'ADN sont stockés à l'intérieur de vésicules formées à partir de membranes à auto-assemblage. Les vésicules peuvent être des protocellules, des liposomes, des micelles, des colloïdosomes, des protéinosomes ou des coacervats. Les vésicules peuvent comprendre une fonctionnalisation de surface pour améliorer l'encapsulation de polynucléotides et/ou lier des polynucléotides ayant des séquences spécifiques. L'encapsulation dans des vésicules permet de protéger les polynucléotides. Une protection supplémentaire est fournie par l'ajout d'un ou de plusieurs stabilisateurs. Le stabilisant peut être des stabilisateurs d'acide nucléique qui stabilisent les polynucléotides ou peuvent être une couche structurale protectrice autour des vésicules telles qu'une couche de silice. L'invention concerne un processus de stockage stable de polynucléotides dans des vésicules et un procédé de récupération de polynucléotides stockés à partir de vésicules. Les polynucléotides peuvent être utilisés pour le stockage d'informations numériques.
Also published as
Latest bibliographic data on file with the International Bureau