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1. WO2020091965 - DIGITAL IMAGING SYSTEM AND METHOD

Publication Number WO/2020/091965
Publication Date 07.05.2020
International Application No. PCT/US2019/055458
International Filing Date 09.10.2019
IPC
G02B 21/36 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
36arranged for photographic purposes or projection purposes
G01N 15/14 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation
G06K 9/00 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G06T 7/00 2017.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7Image analysis
G02B 21/24 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
24Base structure
CPC
G01N 15/1475
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1468with spatial resolution of the texture or inner structure of the particle
1475using image analysis for extracting features of the particle
G02B 21/24
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
24Base structure
G02B 21/367
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
36arranged for photographic purposes or projection purposes
365Control or image processing arrangements for digital or video microscopes
367providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
G06K 9/00127
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
00127Acquiring and recognising microscopic objects, e.g. biological cells and cellular parts
G06K 9/00134
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
00127Acquiring and recognising microscopic objects, e.g. biological cells and cellular parts
00134Acquisition, e.g. centering the image field
G06K 9/2054
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
20Image acquisition
2054Selective acquisition/locating/processing of specific regions, e.g. highlighted text, fiducial marks, predetermined fields, document type identification
Applicants
  • HOLOGIC, INC. [US]/[US]
Inventors
  • JENOSKI, Raymond
  • MAYER, Sid
  • JENNINGS, Robert
  • OLIVA, Ryan, P.
  • MCCROREY, John, A.
  • QUICK, Michael, D.
  • HARRINGTON, Sarah, Margaret
Agents
  • BURSE, David, T.
  • LEUNG, Kevin, K.
Priority Data
62/755,15102.11.2018US
62/755,29102.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIGITAL IMAGING SYSTEM AND METHOD
(FR) SYSTÈME ET PROCÉDÉ D'IMAGERIE NUMÉRIQUE
Abstract
(EN)
Automated systems and methods for evaluating specimens affixed to substrates, such as slides, an exemplary system including a slide imager configured for acquiring a plurality of micro images of a specimen affixed to an substrate, the specimen including a plurality of objects distributed within a three-dimensional volume, and for generating a whole specimen image of the specimen using the micro images, wherein objects contained in the specimen are depicted substantially in focus in the whole specimen image regardless of a z-depth of the respective objects within the specimen. The whole specimen image is stored on a storage medium for subsequent review by a cytotechnologist using a computer-controlled review station including a display and a user interface, wherein the review station user interface is configured such that the cytotechnologist can review and classify the stored whole specimen images.
(FR)
La présente invention concerne des systèmes et des procédés automatisés pour évaluer des échantillons fixés à des substrats, tels que des lames, un système donné à titre d'exemple comprenant un imageur de lame configuré pour acquérir une pluralité de micro-images d'un échantillon fixé à un substrat, l'échantillon comprenant une pluralité d'objets distribués à l'intérieur d'un volume tridimensionnel, et pour générer une image d'échantillon entier de l'échantillon à l'aide des micro-images, des objets contenus dans l'échantillon étant représentés sensiblement mis au point dans l'image d'échantillon entier indépendamment d'une profondeur z des objets respectifs à l'intérieur de l'échantillon. L'image d'échantillon entier est stockée sur un support de stockage pour l'examen ultérieur par un cytotechnologue à l'aide d'un poste d'examen commandée par ordinateur qui comprend un dispositif d'affichage et une interface utilisateur, l'interface utilisateur de poste d'examen étant configurée de telle sorte que le cytotechnologue puisse examiner et classifier les images d'échantillons entiers stockées.
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