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1. WO2020091944 - GENOMIC AND IMMUNE INFILTRATION DIFFERENCES BETWEEN MSI AND MSS GI TUMORS

Publication Number WO/2020/091944
Publication Date 07.05.2020
International Application No. PCT/US2019/054567
International Filing Date 03.10.2019
IPC
A61K 35/17 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants
  • NANTOMICS, LLC [US]/[US]
Inventors
  • NEWTON, Yulia
  • VASKE, Charles
  • SZETO, Christopher
  • REDDY, Sandeep K.
  • BENZ, Stephen Charles
Agents
  • FESSENMAIER, Martin
  • PHUKAN, Priti D.
Priority Data
62/753,72231.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENOMIC AND IMMUNE INFILTRATION DIFFERENCES BETWEEN MSI AND MSS GI TUMORS
(FR) DIFFÉRENCES D'INFILTRATION GÉNOMIQUES ET IMMUNITAIRES ENTRE DES TUMEURS GI MSI ET MSS
Abstract
(EN)
Contemplated systems and methods are directed to omics analysis for GI cancers with respect to MSI status. Certain cancers had significant differences in their pathway activity, checkpoint gene expression, and expression of TME genes, and the inventors contemplate that such differences can be used to further improve treatment outcome prediction of cancers with regard to immune therapy.
(FR)
Les systèmes et les procédés selon l'invention concernent une analyse omique de cancers GI quant au statut MSI. Certains cancers présentent des différences considérables dans l'activité de leur voie, leur expression génique de points de contrôle et leur expression des gènes TME, et les inventeurs proposent que de telles différences puissent être utilisées pour améliorer davantage la prédiction du résultat de traitement de cancers en ce qui concerne l'immunothérapie.
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