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1. WO2020091632 - NOVEL METHOD FOR PRODUCING N,N'-BIS[2-(1Н-IMIDAZOL-4-YL)ETHYL]MALONAMIDE

Publication Number WO/2020/091632
Publication Date 07.05.2020
International Application No. PCT/RU2019/050199
International Filing Date 25.10.2019
IPC
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 239/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
CPC
C07C 239/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
239Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ФАРМИНТЕРПРАЙСЕЗ" OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES" [RU]/[RU]
Inventors
  • НЕБОЛЬСИН, Владимир Евгеньевич NEBOLSIN, Vladimir Evgenievich
  • КРОМОВА, Татьяна Александровна KROMOVA, Tatyana Alexandrovna
Agents
  • ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ЮРИДИЧЕСКАЯ ФИРМА ГОРОДИССКИЙ И ПАРТНЕРЫ" LAW FIRM "GORODISSKY & PARTNERS" LTD.
Priority Data
201813800429.10.2018RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) NOVEL METHOD FOR PRODUCING N,N'-BIS[2-(1Н-IMIDAZOL-4-YL)ETHYL]MALONAMIDE
(FR) NOUVEAU PROCÉDÉ DE PRODUCTION DE N,N’-BIS[2-(1H-IMIDAZOL-4-IL)ÉTHYL]MALONAMIDE
(RU) НОВЫЙ СПОСОБ ПОЛУЧЕНИЯ N,N'-БИС[2-(1Н-ИМИДАЗОЛ-4-ИЛ)ЭТИЛ]МАЛОНАМИДА
Abstract
(EN)
A method for producing N,N'-bis[2-(1Н-imidazol-4-yl)ethyl]malonamide having formula (I) by reacting dimethyl malonate with histamine in a polar organic solvent at a temperature of 85-120°С, said method including a step of crystallization from water and/or the polar organic solvent. The method makes it possible to produce a product having a purity of 99.0 wt.% and is suitable for producing a substance in the pharmaceutical industry.
(FR)
Le procédé de production de N,N'-bis[2-(1H-imidazol-4-il)éthyl]malonamide ayant la formule (I) par une réaction de diméthylmalonate avec une histamine dans un solvant polaire organique 5 à une température de 85-120°C comprenant un stade de cristallisation à partir d’eau et/ou du solvant organique polaire. Le procédé permet d’obtenir un produit ayant une pureté de 99,0 % en masse et est conçu pour obtenir la substance en industrie pharmaceutique.
(RU)
Способ получения N,N'-бис[2-(1Н-имидазол-4-ил)этил]малонамида формулы (I) реакцией диметилмалоната с гистамином в полярном органическом 5 растворителе при температуре 85-120°С, включающий стадию кристаллизации из воды и/или полярного органического растворителя. Способ позволяет получать продукт чистотой от 99, 0 мас% и пригоден для получения субстанции в фармацевтической промышленности.
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