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1. WO2020091513 - COMPOSITION COMPRISING TLR INHIBITING PEPTIDE FOR PREVENTING OR TREATING LUPUS

Publication Number WO/2020/091513
Publication Date 07.05.2020
International Application No. PCT/KR2019/014728
International Filing Date 01.11.2019
IPC
A61K 38/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/07 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 5/103 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
103the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • 주식회사 젠센 GENESEN CO., LTD. [KR]/[KR]
  • 아주대학교 산학협력단 AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 최상돈 CHOI, Sangdun
  • 권혁권 KWON, Hyuk Kwon
  • 신현준 SHIN, Hyeon Jun
  • 계향애 GUI, Xiangai
  • 서창희 SUH, Chang Hee
Agents
  • 제일특허법인(유) FIRSTLAW P.C.
Priority Data
10-2018-013367902.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION COMPRISING TLR INHIBITING PEPTIDE FOR PREVENTING OR TREATING LUPUS
(FR) COMPOSITION COMPRENANT UN PEPTIDE INHIBITEUR DE TLR POUR PRÉVENIR OU TRAITER LE LUPUS
(KO) TLR 억제 펩타이드를 포함하는 루푸스 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition comprising a peptide inhibiting the toll-like receptor (TLR) signaling pathway as an active ingredient for preventing or treating lupus. The pharmaceutical composition according to the present invention effectively regulates factors associated with lupus symptoms in a lupus mouse model and as such, is effective for preventing or treating lupus.
(FR)
La présente invention concerne une composition pharmaceutique comprenant un peptide inhibant la voie de signalisation du récepteur de type toll (TLR) en tant que principe actif pour prévenir ou traiter le lupus. La composition pharmaceutique selon la présente invention régule efficacement des facteurs associés aux symptômes du lupus dans un modèle de lupus chez la souris et, en tant que tel, est efficace pour prévenir ou traiter le lupus.
(KO)
본 발명은 TLR(Toll-like receptor) 신호전달 경로를 억제하는 펩타이드를 유효성분으로 포함하는 루푸스 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 약학적 조성물은 루푸스 마우스 모델에서 루푸스 증상 관련 인자들을 효과적으로 조절하므로, 루푸스를 예방 또는 치료하는데 유용하다.
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