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1. WO2020091472 - PRODUCTION OF TRANSGENIC DOG OVER-EXPRESSING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR δ (PPARδ) IN MUSCLE-SPECIFIC MANNER

Publication Number WO/2020/091472
Publication Date 07.05.2020
International Application No. PCT/KR2019/014634
International Filing Date 31.10.2019
IPC
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
C12N 15/86 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
A01K 67/027 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
Applicants
  • 서울대학교산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
Inventors
  • 오현주 OH, Hyun Ju
  • 김건아 KIM, Geon A
  • 김민정 KIM, Min Jung
  • 이석희 LEE, Seok Hee
  • 이병천 LEE, Byeong Chun
Agents
  • 특허법인 아이피에스 IPS PATENT FIRM
Priority Data
10-2018-013149931.10.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PRODUCTION OF TRANSGENIC DOG OVER-EXPRESSING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR δ (PPARδ) IN MUSCLE-SPECIFIC MANNER
(FR) PRODUCTION D'UN CHIEN TRANSGÉNIQUE SUREXPRIMANT LE RÉCEPTEUR δ ACTIVÉ DE LA PROLIFÉRATION DES PEROXYSOMES (PPAR δ) D'UNE MANIÈRE SPÉCIFIQUE AU MUSCLE
(KO) 근육 특이적 퍼옥시좀 증식체 활성화 수용체 델타(PPARδ) 과발현 형질전환 개 생산
Abstract
(EN)
The present invention relates to a transgenic dog over-expressing peroxisome proliferator-activated receptor δ (PPARδ) in a muscle-specific manner, a production method therefor, and a use thereof, and, specifically, to using, as an animal model having increased motor ability due to slow-twitch muscle generation and an increase in muscular endurance, a a dog transformed in order to over-express PPARδ proteins specifically in muscle tissues.
(FR)
La présente invention concerne un chien transgénique surexprimant le récepteur δ activé de la prolifération des peroxysomes (PPARδ) d'une manière spécifique au muscle, son procédé de production et son utilisation et, plus particulièrement, l'utilisation, en tant que modèle animal ayant des facultés motrices accrues due à une génération de muscle à contractions lentes et à une augmentation de l'endurance musculaire, d'un chien transformé afin de surexprimer les protéines de PPARδ spécifiquement dans les tissus musculaires.
(KO)
본 발명은 근육 특이적으로 퍼옥시좀 증식체 활성화 수용체 델타(PPARδ)를 과발현하는 형질전환 개 및 이의 제조방법, 그리고 이의 이용에 관한 것으로, 특히 근육 조직에서 특이적으로 PPARδ 단백질을 과발현하도록 형질전환된 개를 지근 생성 및 근 지구력의 증가로 인한 운동능이 향상된 동물 모델로 이용하는 것에 관한 것이다.
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