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1. WO2020091463 - PHARMACEUTICAL COMPOSITION COMPRISING ISOLATED MITOCHONDRIA FOR PREVENTING OR TREATING TENDINOPATHY

Publication Number WO/2020/091463
Publication Date 07.05.2020
International Application No. PCT/KR2019/014605
International Filing Date 31.10.2019
IPC
A61K 35/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 21/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
Applicants
  • 차의과학대학교 산학협력단 CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 최용수 CHOI, Yong-Soo
  • 이지민 LEE, Ji Min
  • 김미진 KIM, Mi Jin
  • 민경훈 MIN, Kyunghoon
Agents
  • 제일특허법인(유) FIRSTLAW P.C.
Priority Data
10-2018-013221131.10.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION COMPRISING ISOLATED MITOCHONDRIA FOR PREVENTING OR TREATING TENDINOPATHY
(FR) COMPOSITION PHARMACEUTIQUE COMPORTANT DES MITOCHONDRIES ISOLÉES POUR PRÉVENIR OU TRAITER LA TÉNOPATHIE
(KO) 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition for preventing or treating tendinopathy, comprising isolated mitochondria as an effective component. The pharmaceutical composition of the present invention, comprising isolated mitochondria as an effective component, can restore the ATP synthesis capacity and antioxidant capacity of tenocytes damaged by inflammations to a normal tenocyte level. In addition, the pharmaceutical composition of the present invention, when administered to damaged tenocytes, inhibits the expression of an apoptosis promoter, Bax, and increases the expression of an apoptosis inhibitor, Blc-2. In addition, the pharmaceutical composition of the present invention, when administered to damaged tenocytes, can restore the expression of MMP1 to a normal tenocyte level. Accordingly, the pharmaceutical composition of the present invention may be beneficially used in the prevention or treatment of tendinopathy.
(FR)
La présente invention concerne une composition pharmaceutique pour prévenir ou traiter la ténopathie, comprenant comme principe actif des mitochondries isolées. La composition pharmaceutique de la présente invention, qui comport comme principe actif des mitochondries isolées, peut restaurer la capacité de synthèse d'ATP et la capacité antioxydante de ténocytes endommagés par l'inflammation à des niveaux correspondant à ceux de ténocytes normaux. De plus, la composition pharmaceutique de la présente invention, lorsqu'elle est administrée à des ténocytes endommagés, inhibe l'expression d'un promoteur de l'apoptose, Bax, et augmente l'expression d'un inhibiteur de l'apoptose, Blc-2. De plus, la composition pharmaceutique de la présente invention, lorsqu'elle est administrée à des ténocytes endommagés, peut restaurer l'expression de la MMP1 à un niveau correspondant à celui de ténocytes normaux. Par conséquent, la composition pharmaceutique de la présente invention peut être utilisée de manière bénéfique dans la prévention et le traitement de la ténopathie.
(KO)
본 발명은 분리된 미토콘드리아를 유효성분으로 포함하는 건병증 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 미토콘드리아를 유효성분으로 포함하는 약학 조성물은 염증반응에 의해 손상된 건세포의 ATP 합성능 및 항산화능을 정상 건세포 수준으로 회복시킬 수 있다. 또한, 본 발명의 약학 조성물을 손상된 건세포에 투여할 경우, 세포사멸 인자인 Bax의 발현을 억제하며, 세포사멸 억제 인자인 Blc-2의 발현을 증가시킨다. 또한, 본 발명의 약학 조성물을 손상된 건세포에 투여할 경우, MMP1의 발현을 정상 건세포 수준으로 회복시킬 수 있다. 따라서, 본 발명의 약학 조성물은 건병증을 예방 또는 치료하는데 유용하게 사용될 수 있다.
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