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1. WO2020091430 - COMPOSITION FOR PREVENTION OR TREATMENT OF MACULAR DEGENERATION

Publication Number WO/2020/091430
Publication Date 07.05.2020
International Application No. PCT/KR2019/014500
International Filing Date 30.10.2019
IPC
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
Applicants
  • 경북대학교 산학협력단 KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 박동호 PARK, Dong Ho
  • 이인규 LEE, In Kyu
Agents
  • 윤대웅 YOON, Dae Woong
Priority Data
10-2018-013367702.11.2018KR
10-2019-013677130.10.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTION OR TREATMENT OF MACULAR DEGENERATION
(FR) COMPOSITION DE PRÉVENTION OU DE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE
(KO) 황반변성 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition for prevention or treatment of macular degeneration, containing fursultiamine or salts thereof. Fursulthiamine reduces the expression of HIF-1α which is increased in retinal pigment epithelial cells, and inhibits the growth of choroidal vascular endothelial cells. A pharmaceutical composition of the present invention containing fursultiamine or salts thereof can also be used as an agent for treatment of various neovascular eye diseases.
(FR)
La présente invention concerne une composition pharmaceutique qui permet de prévenir ou de traiter la dégénérescence maculaire et qui contient de la fursultiamine ou des sels de celle-ci. La fursulthiamine fait diminuer l'expression de l'HIF-1α qui est augmentée dans les cellules de l'épithélium pigmentaire rétinien, et inhibe la croissance des cellules endothéliales vasculaires choroïdiennes. Une composition pharmaceutique de la présente invention contenant de la fursultiamine ou des sels de celle-ci peut également être utilisée comme agent destiné au traitement de diverses maladies oculaires liées à une néovascularisation.
(KO)
본 발명은 푸르설티아민(fursultiamine) 또는 이의 염(salts)을 포함하는, 황반변성 (macular degeneration) 예방 또는 치료용 약제학적 조성물에 관한 것이다. 푸르설티아민은 망막색소상피세포에서 증가된 HIF-1α의 발현을 감소시키고, 맥락막 혈관내피세포 성장을 억제한다. 본 발명의 푸르설티아민(fursultiamine) 또는 이의 염(salts)을 포함하는 약제학적 조성물은 다양한 신생혈관성 안질환의 치료제로도 사용될 수 있다.
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