Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020091423 - PHYTOCHEMICAL-FRUCTOOLIGOSACCHARIDE CONJUGATE, METHOD FOR PRODUCING SAME, AND USE THEREOF

Publication Number WO/2020/091423
Publication Date 07.05.2020
International Application No. PCT/KR2019/014489
International Filing Date 30.10.2019
IPC
C07H 3/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
C07H 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
A23L 29/00 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
29Foods or foodstuffs containing additives; Preparation or treatment thereof
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
B01J 31/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
02containing organic compounds or metal hydrides
Applicants
  • 명지대학교 산학협력단 MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 서주원 SUH, Joo Won
  • 말리야칼 존슨엘딘 MALIYAKKAL JOHNSON, Eldin
  • 이한기 LEE, Han Ki
Agents
  • 임상엽 LIM, Sang Yeob
Priority Data
10-2018-013099030.10.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PHYTOCHEMICAL-FRUCTOOLIGOSACCHARIDE CONJUGATE, METHOD FOR PRODUCING SAME, AND USE THEREOF
(FR) CONJUGUÉ AGENT PHYTOCHIMIQUE-FRUCTO-OLIGOSACCHARIDE, SON PROCÉDÉ DE PRODUCTION ET SON UTILISATION
(KO) 파이토케미컬-프럭토올리고당 결합체, 이의 제조방법 및 이의 용도
Abstract
(EN)
The present invention provides a novel phytochemical-fructooligosaccharide conjugate having a structure in which a phytochemical in the form of phenolic acid is conjugated to a portion of saccharides constituting a fructooligosaccharide backbone. Compared to corresponding phenolic acid phytochemicals, the novel phytochemical-fructooligosaccharide conjugate according to the present invention is hardly decomposed under oral-gastrointestinal transit conditions such that most of the phytochemical-fructooligosaccharide conjugate can reach the large intestine. Thus, the novel phytochemical-fructooligosaccharide conjugate has good bioavailability in the large intestine when orally administered. In particular, a ferulic acid-fructooligosaccharide conjugate according to the present invention has an excellent colorectal cancer cell-selective killing effect as compared to commercial colorectal cancer treatment drugs, and can thus be used as a food or pharmaceutical material useful for preventing, alleviating, or treating colorectal cancer.
(FR)
La présente invention concerne un nouveau conjugué agent phytochimique-fructo-oligosaccharide ayant une structure selon laquelle un agent phytochimique sous forme d'acide phénolique est conjugué à une partie de saccharides constituant un squelette de fructo-oligosaccharide. Par comparaison avec des produits phytochimiques d'acide phénolique correspondants, le nouveau conjugué agent phytochimique-fructo-oligosaccharide selon la présente invention est difficilement décomposé dans des conditions de transit gastro-intestinaux, de telle sorte que la majeure partie du conjugué agent phytochimique-fructo-oligosaccharide peut atteindre le gros intestin. Ainsi, le nouveau conjugué agent phytochimique-fructo-oligosaccharide présente une bonne biodisponibilité dans le gros intestin lorsqu'il est administré par voie orale. En particulier, un conjugué acide férulique-fructo-oligosaccharide selon la présente invention a un excellent effet d'élimination sélective de cellules du cancer colorectal par comparaison avec des médicaments de traitement du cancer colorectal présents dans le commerce, et peut ainsi être utilisé en tant que produit alimentaire ou pharmaceutique utile pour prévenir, soulager ou traiter le cancer colorectal.
(KO)
본 발명은 페놀산(Phenolic acid) 형태의 파이토케미컬(Phytochemical)이 프럭토올리고당 주쇄를 구성하는 일부 당에 결합된 구조를 가지는 신규 파이토케미컬-프럭토올리고당 결합체를 제공한다. 본 발명에 따른 신규 파이토케미컬-프럭토올리고당 결합체는 이에 대응되는 페놀산 파이토케미컬에 비해 구강-위장관 통과 조건에서 거의 분해되지 않고 대부분이 대장에 도달할 수 있으므로 경구 투여시 대장에서 우수한 생체이용성을 갖는다. 특히, 본 발명에 따른 페룰산-프럭토올리고당 결합체는 상업적인 대장암 치료용 약물과 비교하였을 때 대장암 세포에 대한 선택적 사멸 효과가 우수하여, 대장암을 예방, 개선 또는 치료하는데에 유용한 식의약 소재로 사용될 수 있다.
Latest bibliographic data on file with the International Bureau