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1. WO2020091052 - THERAPEUTIC AGENT FOR ARTHRITIS

Publication Number WO/2020/091052
Publication Date 07.05.2020
International Application No. PCT/JP2019/043057
International Filing Date 01.11.2019
IPC
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
Applicants
  • 国立大学法人大阪大学 OSAKA UNIVERSITY [JP]/[JP]
Inventors
  • 石井 優 ISHII, Masaru
  • 菊田 順一 KIKUTA, Junichi
  • 長谷川 哲雄 HASEGAWA, Tetsuo
Agents
  • 山尾 憲人 YAMAO, Norihito
  • 新田 昌宏 NITTA, Masahiro
Priority Data
2018-20720902.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) THERAPEUTIC AGENT FOR ARTHRITIS
(FR) AGENT THÉRAPEUTIQUE POUR L'ARTHRITE
(JA) 関節炎治療剤
Abstract
(EN)
The present invention addresses the problem of providing a therapeutic agent for arthritis, which contains a low-molecular-weight FoxM1 inhibitor, e.g., thiostrepton, as an active ingredient. FoxM1 is expressed in an osteoclast progenitor that occurs specifically in an inflamed synovium in arthritis, and is not involved in the function of an osteoclast that is present in the bone marrow in a normal person and is involved in normal bone metabolism. Therefore, arthritis can be prevented and/or treated without any adverse side effect by using a FoxM1 inhibitor.
(FR)
La présente invention traite du problème de la fourniture d'un agent thérapeutique pour l'arthrite, qui contient un inhibiteur de FoxM1 de faible poids moléculaire, par exemple le thiostrepton, en tant que principe actif. FoxM1 est exprimé dans un progéniteur d'ostéoclastes qui se produit spécifiquement dans une synovite enflammée dans l'arthrite, et n'est pas impliqué dans la fonction d'un ostéoclaste présent dans la moelle osseuse chez une personne normale et qui est impliqué dans le métabolisme osseux normal. Par conséquent, l'arthrite peut être prévenue et/ou traitée sans aucun effet secondaire indésirable en utilisant un inhibiteur de FoxM1.
(JA)
本発明は、例えばチオストレプトンのような、低分子FoxM1阻害剤を有効成分とする、関節炎治療剤を提供する。FoxM1は、関節炎の炎症性滑膜に特異的に出現する破骨前駆細胞に発現し、健常者の骨髄中にあって通常の骨代謝に関与する破骨細胞の機能には関与していないので、FoxM1阻害剤を用いることで、副作用を伴うことなく、関節炎の予防および/または治療が可能である。
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