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1. WO2020091035 - MATERIAL FOR BONE REGENERATION HAVING SURFACE INCLUDING HYDROPHILIZED BIODEGRADABLE FIBERS, AND PRODUCTION METHOD THEREFOR

Publication Number WO/2020/091035
Publication Date 07.05.2020
International Application No. PCT/JP2019/043010
International Filing Date 01.11.2019
IPC
A61L 27/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
02Inorganic materials
12Phosphorus-containing materials, e.g. apatite
A61L 27/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
A61L 27/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
18obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/32 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
30Inorganic materials
32Phosphorus-containing materials, e.g. apatite
A61L 27/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
40Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 27/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
58Materials at least partially resorbable by the body
Applicants
  • 国立大学法人 名古屋工業大学 NAGOYA INSTITUTE OF TECHNOLOGY [JP]/[JP]
  • ORTHOREBIRTH株式会社 ORTHOREBIRTH CO., LTD. [JP]/[JP]
Inventors
  • 春日 敏宏 KASUGA Toshihiro
  • 松原 孝至 MATSUBARA Takashi
  • 渡部 将央 WATABE Masao
  • 大坂 直也 OSAKA Naoya
Agents
  • 二宮 克之 NINOMIYA Katsuyuki
Priority Data
62/755,38702.11.2018US
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) MATERIAL FOR BONE REGENERATION HAVING SURFACE INCLUDING HYDROPHILIZED BIODEGRADABLE FIBERS, AND PRODUCTION METHOD THEREFOR
(FR) MATÉRIAU POUR LA RÉGÉNÉRATION OSSEUSE PRÉSENTANT UNE SURFACE COMPRENANT DES FIBRES BIODÉGRADABLES HYDROPHILISÉES ET PROCÉDÉ DE PRODUCTION ASSOCIÉ
(JA) 表面が親水化された生分解性繊維からなる骨再生用材料、及びその製造方法
Abstract
(EN)
The polymer surface of biodegradable fibers included in materials for bone regeneration has water repellency and hydrophobicity, and therefore, when such a material is implanted into an affected area, the material repels blood at a very early stage of being mixed with blood, and therefore it takes a long time for the material to be incorporated during an operation. This material for bone regeneration has a surface including hydrophilized biodegradable fibers, wherein the biodegradable fibers included in the material for bone regeneration contain osteogenic particles, and the surfaces of the biodegradable fibers are each substantially entirely covered by an amorphous calcium phosphate layer, and a portion of the calcium phosphate of the amorphous calcium phosphate layer includes carbonate apatite in which the crystal structure of calcium phosphate is replaced with calcium carbonate.
(FR)
La surface polymère de fibres biodégradables incluses dans des matériaux pour la régénération osseuse présente une répulsion de l'eau et une hydrophobie et, par conséquent, lorsqu'un tel matériau est implanté dans une zone touchée, le matériau repousse le sang à un stade très précoce du mélange avec le sang et, par conséquent, l'incorporation du matériau pendant une intervention peut prendre une longue période de temps. Selon l'invention, le matériau pour la régénération osseuse présente une surface comprenant des fibres biodégradables hydrophilisées, les fibres biodégradables incluses dans le matériau pour la régénération osseuse contenant des particules ostéogènes et les surfaces des fibres biodégradables sont toutefois pratiquement entièrement recouvertes d'une couche de phosphate de calcium amorphe et une partie du phosphate de calcium de la couche de phosphate de calcium amorphe comprend de l'apatite de carbonate dans laquelle la structure cristalline de phosphate de calcium est remplacée par du carbonate de calcium.
(JA)
骨再生用材料を構成する生分解性繊維のポリマー表面は撥水性、疎水性を有するため、患部に材料をインプラントする際、血液との混和の最初期に弾いてしまうので、手術中の賦形にかかる時間が伸びてしまう。 表面が親水化された生分解性繊維からなる骨再生用材料であって、前記骨再生用材料を構成する前記生分解性繊維は骨形成性粒子を含有しており、前記生分解性繊維の表面の実質的に全域が非晶質リン酸カルシウム層で被覆されており、前記非晶質リン酸カルシウム層は、リン酸カルシウムの一部に結晶構造が炭酸カルシウムで置換された炭酸アパタイトを含む。
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