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1. WO2020089944 - PROCESS FOR PREPARING AN HERBAL EXTRACT AND COMPOSITIONS THEREOF

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[ EN ]

We Claim,

1. A process for preparing an herbal extract comprising phytochemical (s) and resins, the said process comprising;

(a) grinding an herbal source into a fine powder;

(b) subjecting the powder to CCh/solvent extraction to obtain a whole herbal extract containing phytochemical(s)/active ingredients, resins, gums, wax, triglycerides, fatty acids, active ingredients and volatile oils;

(c) subjecting the extract of step(b) to solvent distillation followed by vacuum drying to remove solvent;

(d) subj ecting the extract of step(c) to steam distillation to remove volatile oils;

(e) subjecting the extract of step(d) to extraction with a non-polar solvent to remove triglycerides (fat), soft resins, fixed oil, gums, wax and fatty acids;

(f) subjecting the extract of step(e) to solvent distillation and/or vacuum drying to remove the non-polar solvent and obtain dry flakes;

(g) milling the flakes of step (f) into a fine powder and vacuum drying the powder to obtain a solvent free and low moisture extract comprising phytochemicals and hard resins;

wherein the concentration of total curcuminoids and resins is in a ratio ranging from 1 : 9 to 9: 1.

2. The process for preparing an herbal extract as claimed in claim 1, wherein the first solvent for extracting the herbal extract in step (b) is selected from the group comprising CO2, methanol, ethanol, ethyl acetate, l-Ethyl-3-(3- dimethylaminopropyl) carbodiimide (EDC), and combinations thereof.

3. The process for preparing an herbal extract as claimed in claim 1, wherein the process of extraction of the herbal extract in step (b) is performed at a temperature of uptol80°C and wherein the distillation process in step (c) is performed at 50°C to l00°C and vacuum drying is performed at 1 to 50 mBars vacuum and at a temperature ranging from lO°C to 80°C.

4. The process for preparing an herbal extract as claimed in claim 1, wherein the non-polar solvent hexane/n-hexane was added to the herbal extract in a 1 :2 ratio in step (e) and blended at room temperature.

5. The process for preparing an herbal extract as claimed in claim 1, wherein the process for extracting curcuminoids and resins from Curcuma longa comprising;

(a) grinding the dry Curcuma longa rhizome parts into a fine powder;

(b) subjecting the powder to CO2 or ethyl acetate or ethanol extraction to obtain a whole herbal extract containing curcuminoids, resins, gums, wax, triglycerides, fixed oil, fatty acids, active ingredients and volatile oils;

(c) subjecting the extract of step(b) to solvent distillation, concentration/ vacuum drying to remove solvent;

(d) subjecting the extract of step(c) to steam distillation to remove volatile oils;

(e) subjecting the extract of step(d) to extraction with a non-polar solvent to remove soft resins, triglycerides, fixed oil, wax, gums and fatty acids;

(f) subjecting the extract of step(e) to solvent distillation, drying or vacuum drying to remove the non-polar solvent and obtain dry flakes;

(g) Milling the flakes of step (f) into a fine powder and vacuum drying the powder to obtain a solvent free and low moisture extract comprising curcuminoids and hard resins;

wherein the concentration of total curcuminoids and resins is in a ratio ranging from 1 : 9 to 9: 1, preferably in a ratio of 1 : 1.

6. The process for preparing an herbal extract as claimed in claim 5, wherein the curcuminoids are selected from the group comprising curcumin, demethoxycurcumin and Bisdemethoxy curcumin.

7. The process for preparing an herbal extract as claimed in claim 5, wherein the herbal extract is in powdered form comprising curcuminoids in a concentration of 25% to 90% and resins in a concentration of 45% to 75%.

8. The process for preparing an herbal extract as claimed in claim 6, wherein the herbal extract comprises curcumin in a concentration ranging from 35% to 70% by weight of the extract, demethoxycurcumin in a concentration ranging from 10% to 40% by weight of the extract and Bisdem ethoxy curcumin in the range of 10 to 40% by weight of the extract.

9. The process for preparing an herbal extract as claimed in claim 6, wherein the herbal extract comprising curcuminoids consisting of curcumin in a concentration ranging from 55% to 70% by weight of the total curcuminoids, Demethoxycurcumin in the range of 20 to 30% by weight of the total curcuminoids and Bisdemethoxy curcumin in the range of 10 to 20% by weight of the total curcuminoids.

10. A highly bioavailable herbal composition comprising the herbal extract prepared by the process as claimed in claim 7 comprising curcuminoids and resins in a ratio ranging from 1 : 9 to 9: 1.