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1. WO2020089842 - PHARMACEUTICAL COMPOSITIONS FOR THE EFFECTIVE TREATMENT OF COLORECTAL CANCER

Publication Number WO/2020/089842
Publication Date 07.05.2020
International Application No. PCT/IB2019/059380
International Filing Date 01.11.2019
IPC
C07C 237/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
20the carbon skeleton containing six-membered aromatic rings
A61K 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 35/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
02from inanimate materials
04Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
Applicants
  • CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITÉCNICO NACIONAL [MX]/[MX]
  • INSTITUTO DE SEGURIDAD Y SERVICIOS SOCIALES DE LOS TRABAJADORES DEL ESTADO [MX]/[MX]
Inventors
  • CRUZ NOVA, Pedro
  • BRISEÑO DÍAZ, Paola
  • VARGAS MEJÍA, Miguel Angel
  • THOMPSON BONILLA, María del Rocío
Agents
  • CARREÑO SÁNCHEZ, Luis Antonio
Priority Data
MX/a/2018/01343801.11.2018MX
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITIONS FOR THE EFFECTIVE TREATMENT OF COLORECTAL CANCER
(FR) COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT EFFICACE DU CANCER COLORECTAL
Abstract
(EN)
The present invention describes pharmaceutical compositions comprising a compound that has the formula (Compound C19), which specifically inhibits mutated GTPase KRAS4b, making the compositions useful for the effective treatment of colorectal cancer. Compound C19 acts as a stabilizer of the KRAS4b-PDEδ complex, decreasing the proliferation of cancer cells in colorectal cancer, and increasing apoptosis through decreased activation of KRAS4b oncogenic signaling.
(FR)
La présente invention concerne des compositions pharmaceutiques comprenant un composé qui est représenté par la formule (composé C19), qui inhibe spécifiquement la GTPase KRAS4b mutée, rendant ces compositions utiles pour le traitement efficace du cancer colorectal. Le composé C19 agit comme un stabilisant du complexe KRAS4b-PDEδ, diminuant ainsi la prolifération de cellules cancéreuses dans le cancer colorectal, et augmentant l'apoptose par l'activation réduite de la signalisation oncogène de KRAS4b.
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