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1. WO2020089841 - BIOMARKERS AND METHODS OF USE FOR RADIATION-INDUCED LUNG INJURY

Publication Number WO/2020/089841
Publication Date 07.05.2020
International Application No. PCT/IB2019/059379
International Filing Date 31.10.2019
IPC
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40against enzymes
C12Y 204/02012
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
204Glycosyltransferases (2.4)
02Pentosyltransferases (2.4.2)
02012Nicotinamide phosphoribosyltransferase (2.4.2.12), i.e. visfatin
G01N 2458/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2458Labels used in chemical analysis of biological material
G01N 2800/12
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
12Pulmonary diseases
G01N 2800/40
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
40Disorders due to exposure to physical agents, e.g. heat disorders, motion sickness, radiation injuries, altitude sickness, decompression illness
G01N 2800/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
50Determining the risk of developing a disease
Applicants
  • GARCIA, Joe G.N. [US]/[US]
Inventors
  • GARCIA, Joe G.N.
Agents
  • PENNY, John J., Jr.
Priority Data
62/753,80231.10.2018US
62/896,48305.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOMARKERS AND METHODS OF USE FOR RADIATION-INDUCED LUNG INJURY
(FR) BIOMARQUEURS ET MÉTHODES D'UTILISATION DE CES BIOMARQUEURS POUR DÉTECTER UNE LÉSION PULMONAIRE RADIO-INDUITE
Abstract
(EN)
The present disclosure is directed to methods (e.g., in vitro methods) for use of nicotinamide phosphoribosyltransferase (NAMPT) as a biomarker in radiation-induced lung injury (RILI). Provided herein is an in vitro method for the diagnosis, prognosis, and/or monitoring of RILI in a human subject by providing a tissue or plasma sample from the subject and detecting the level of NAMPT therein, wherein a higher level of NAMPT in the tissue or plasma sample from the subject compared to a healthy control or a reference value is indicative for the presence of RILI in the subject. Further provided herein is a method of detecting NAMPT in a human subject by obtaining a biological sample from the subject, detecting the presence of NAMPT in the sample by contacting the sample with a capture agent that specifically binds NAMPT, and detecting binding between NAMPT and the capture agent.
(FR)
L'invention concerne des méthodes (des méthodes in vitro, par exemple) d'utilisation de nicotinamide phosphoribosyltransférase (NAMPT) en tant que biomarqueur pour détecter une lésion pulmonaire radio-induite (RILI). L'invention concerne en particulier une méthode in vitro de diagnostic, de pronostic et/ou de surveillance d'une lésion pulmonaire radio induite chez un humain, consistant à obtenir de l'individu un échantillon de tissu ou de plasma et à détecter le niveau de NAMPT qu'il contient, un niveau de NAMPT supérieur dans ledit échantillon par rapport à un témoin sain ou à une valeur de référence indiquant la présence d'une lésion pulmonaire radio-induite chez l'individu en question. L'invention concerne en outre une méthode de détection de NAMPT chez un humain, consistant à obtenir de l'individu un échantillon biologique, à détecter la présence de NAMPT dans l'échantillon par la mise en contact dudit échantillon avec un agent de capture se liant spécifiquement à NAMPT, et à détecter une liaison entre NAMPT et l'agent de capture.
Latest bibliographic data on file with the International Bureau