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1. WO2020089473 - NOVEL AGONISTIC ANTIBODY MOLECULES

Publication Number WO/2020/089473
Publication Date 07.05.2020
International Application No. PCT/EP2019/080003
International Filing Date 01.11.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61P 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07K 16/2818
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2818against CD28 or CD152
C07K 16/2878
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2878against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
C07K 2317/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
Applicants
  • BIOINVENT INTERNATIONAL AB [SE]/[SE]
Inventors
  • FRENDÉUS, Björn
  • TEIGE, Ingrid
  • MÅRTENSSON, Linda
  • HOLMKVIST, Petra
  • SEMMRICH, Monika
Agents
  • DIDMON, Mark
Priority Data
18203996.601.11.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL AGONISTIC ANTIBODY MOLECULES
(FR) NOUVELLES MOLÉCULES D'ANTICORPS AGONISTES
Abstract
(EN)
Described are novel antibody molecules that specifically bind to TNFR2 on a target cell and thereby agonize TNFR2, but that do not block the ligand TNF-α from binding to the TNFR2, Also described is the use of such antibody molecules in medicine, i.a, in treatment of cancer or chronic inflammatory diseases.
(FR)
L'invention concerne de nouvelles molécules d'anticorps qui se lient spécifiquement au TNFR2 sur une cellule cible et ainsi agonisent le TNFR2, mais qui n'empêchent pas le ligand TNF-α de se lier au TNFR2. L'invention concerne également l'utilisation de ces molécules d'anticorps en médecine, entre autres, dans le traitement du cancer ou de maladies inflammatoires chroniques.
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