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1. WO2020089460 - NOVEL UREA 6,7-DIHYDRO-4H-THIAZOLO[5,4-C]PYRIDINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

Publication Number WO/2020/089460
Publication Date 07.05.2020
International Application No. PCT/EP2019/079982
International Filing Date 01.11.2019
IPC
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07D 513/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • AICURIS GMBH & CO. KG [DE]/[DE]
Inventors
  • DONALD, Alastair
  • URBAN, Andreas
  • BONSMANN, Susanne
  • SPRINGER, Jasper
Agents
  • KILGER, Ute
Priority Data
18000875.702.11.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL UREA 6,7-DIHYDRO-4H-THIAZOLO[5,4-C]PYRIDINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
(FR) NOUVELLES URÉE-6,7-DIHYDRO-4 H-THIAZOLO[5,4-C]PYRIDINES ACTIVES CONTRE LE VIRUS DE L'HÉPATITE B (VHB)
Abstract
(EN)
The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
(FR)
La présente invention concerne de manière générale de nouveaux agents antiviraux. Spécifiquement, la présente invention concerne des composés qui peuvent inhiber la ou les protéines codées par le virus de l'hépatite B (VHB) ou interférer avec la fonction du cycle de réplication du VHB, des compositions comprenant de tels composés, des procédés pour inhiber la réplication virale du VHB, des méthodes pour traiter ou prévenir une infection par le VHB, et des procédés et des intermédiaires pour fabriquer les composés.
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