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1. WO2020089343 - METHODS FOR SELECTION AND STIMULATION OF CELLS AND APPARATUS FOR SAME

Publication Number WO/2020/089343
Publication Date 07.05.2020
International Application No. PCT/EP2019/079746
International Filing Date 30.10.2019
IPC
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
A61K 35/17 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C12N 2501/2302
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
2302Interleukin-2 (IL-2)
C12N 2501/2315
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
2315Interleukin-15 (IL-15)
C12N 2501/2321
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
2321Interleukin-21 (IL-21)
C12N 2501/505
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
50Cell markers; Cell surface determinants
505CD4; CD8
C12N 2501/51
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
50Cell markers; Cell surface determinants
51B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
Applicants
  • JUNO THERAPEUTICS GMBH [DE]/[DE]
Inventors
  • GERMEROTH, Lothar
  • STEMBERGER, Christian
  • POLTORAK, Mateusz Pawel
  • SCHMIDT, Thomas
Agents
  • GOODFELLOW, Hugh Robin
  • JACKSON, Richard Eric
  • COCKERTON, Bruce Roger
  • MARSHALL, Cameron John
  • GOODFELLOW, Hugh Robin
  • TUNSTALL, Christopher Stephen
  • KIRSCH, Susan Edith
  • SMALL, Gary James
  • WARNER, James Alexander
  • BRUNNER, John Michael Owen
  • CHAPMAN, Desmond Mark
  • WISE, Daniel Joseph
  • OATES, Edward Christopher
  • MCGUIRE, Gillian Margaret
  • MORRIS, Claire Louise
  • COX, Jennifer Jane
  • GEORGIOU, Matthew
  • HOLLAND, David Christopher
  • BETTRIDGE, Paul Sebastian
  • DRAGOSAVAC, Susannah Marie
  • PREISSNER, Tanja Stephanie
  • LEATHLEY, Anna Elisabeth
  • HUSBAND, Benjamin
  • DUFFIELD, Stephen
  • MACLEOD, Ian Roger
  • HOGGETT, Christopher James
  • GRABENSTEIN, Jens
  • MICHELL, Stephen Robert
  • DARBY, Richard John
  • BARRY, Isobel Amy
  • MCKINLEY, Elizabeth Anne
  • BIRCH, Matthew John
  • THEISEN, Andreas Robert
  • BETTRIDGE, Paul Sebastian
Priority Data
62/753,91131.10.2018US
62/842,51102.05.2019US
62/861,31413.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR SELECTION AND STIMULATION OF CELLS AND APPARATUS FOR SAME
(FR) PROCÉDÉS DE SÉLECTION ET DE STIMULATION DE CELLULES ET APPAREIL ASSOCIÉ
Abstract
(EN)
Provided herein are methods for selecting and stimulating a plurality of cells in a sample of cells using column chromatography, and collecting the cells without using additional steps or reagents to facilitate detachment of the cells from the column. In some aspects, the methods provided herein reduce the time needed to generate a population of selected and stimulated cells useful for genetic engineering, and ultimately, cell therapy, compared to existing methods. Also provided are articles of manufacture and apparatus thereof.
(FR)
Procédés pour sélectionner et stimuler une pluralité de cellules dans un échantillon de cellules à l'aide d'une chromatographie sur colonne, et collecter les cellules sans utiliser d'étapes supplémentaires ou de réactifs pour faciliter le détachement des cellules de la colonne. Dans certains aspects, les procédés selon la présente invention réduisent le temps nécessaire pour générer une population de cellules sélectionnées et stimulées utiles pour une ingénierie génétique, et finalement, une thérapie cellulaire, par comparaison avec des procédés existants. Des produits manufacturés et un appareil correspondant sont en outre décrits.
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