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1. WO2020088641 - JOINT USE OF COMPOUND A AND COMPOUND B IN PREPARATION OF MEDICATIONS FOR TREATMENT OF GOUT OR HYPERURICEMIA

Publication Number WO/2020/088641
Publication Date 07.05.2020
International Application No. PCT/CN2019/114980
International Filing Date 01.11.2019
IPC
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61K 31/426 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 19/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
Applicants
  • 江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN]/[CN]
Inventors
  • 陈建文 CHEN, Jianwen
  • 沈扬 SHEN, Yang
  • 宁睿 NING, Rui
Agents
  • 北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.
Priority Data
201811300282.102.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) JOINT USE OF COMPOUND A AND COMPOUND B IN PREPARATION OF MEDICATIONS FOR TREATMENT OF GOUT OR HYPERURICEMIA
(FR) UTILISATION CONJOINTE DU COMPOSÉ A ET DU COMPOSÉ B DANS LA PRÉPARATION DE MÉDICAMENTS POUR LE TRAITEMENT DE LA GOUTTE OU DE L'HYPERURICÉMIE
(ZH) 化合物A与化合物B联合在制备治疗痛风或高尿酸血症的药物中的用途
Abstract
(EN)
The present disclosure relates to the joint use of compound A and compound B in the preparation of medications for the treatment of gout or hyperuricemia. Specifically, compound A is selected from the compound shown in Formula I, a pharmaceutical salt thereof, or an ester thereof, and compound B is selected from allopurinol or febuxostat. In particular, a method for treating gout or hyperuricemia in which the compound shown in Formula I-1 works in conjunction with febuxostat shows good treatment effect.
(FR)
La présente invention concerne l'utilisation conjointe du composé A et du composé B dans la préparation de médicaments pour le traitement de la goutte ou de l'hyperuricémie. Plus précisément, le composé A est choisi parmi le composé représenté par la formule I, un sel pharmaceutique de celui-ci, ou un ester de celui-ci, et le composé B est choisi parmi l'allopurinol ou le fébuxostat. En particulier, l'invention concerne un procédé de traitement de la goutte ou de l'hyperuricémie dans lequel le composé représenté dans la formule I-1 agit conjointement avec le fébuxostat et présente un bon effet de traitement.
(ZH)
本公开涉及化合物A与化合物B联合在制备治疗痛风或高尿酸血症的药物中的用途。具体而言,化合物A选自式(I)化合物、或其可药用盐、或其酯,化合物B选自别嘌呤醇、非布司他。尤其是式(I-1)化合物联合非布司他治疗痛风或高尿酸血症的方法,显示了良好的治疗效果
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