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1. WO2020088270 - APPLICATION OF KYNURENIC ACID OR DERIVATIVE THEREOF IN PREPARING DRUG FOR IMPROVING PATHOLOGICAL DAMAGES ASSOCIATED WITH CHRONIC PSYCHOLOGICAL STRESS

Publication Number WO/2020/088270
Publication Date 07.05.2020
International Application No. PCT/CN2019/111867
International Filing Date 18.10.2019
IPC
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
CPC
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
Applicants
  • 中国药科大学 CHINA PHARMACEUTICAL UNIVERSITY [CN]/[CN]
Inventors
  • 郝海平 HAO, Haiping
  • 郑啸 ZHENG, Xiao
  • 杨鹏 YANG, Peng
Agents
  • 南京苏高专利商标事务所(普通合伙) NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP )
Priority Data
201811269300.429.10.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) APPLICATION OF KYNURENIC ACID OR DERIVATIVE THEREOF IN PREPARING DRUG FOR IMPROVING PATHOLOGICAL DAMAGES ASSOCIATED WITH CHRONIC PSYCHOLOGICAL STRESS
(FR) APPLICATION D'ACIDE KYNURÉNIQUE OU D'UN DÉRIVÉ DE CELUI-CI DANS LA PRÉPARATION DE MÉDICAMENT POUR AMÉLIORER DES DOMMAGES PATHOLOGIQUES ASSOCIÉS À UN STRESS PSYCHOLOGIQUE CHRONIQUE
(ZH) 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用
Abstract
(EN)
An application of kynurenic acid or derivative thereof in preparing a drug for improving pathological damages associated with chronic psychological stress. Compared with the prior art, disclosed is an application of kynurenic acid or derivative thereof in preparing a drug for improving pathological damages associated with chronic psychological stress. Related researches prove that oral administration of kynurenic acid has a good effect in improving impaired social interaction, inflammatory disorders of the central nervous system, and splenic immune dysregulation associated with chronic psychological stress.
(FR)
L'invention concerne une application d'acide kynurénique ou d'un dérivé de celui-ci dans la préparation d'un médicament pour améliorer des dommages pathologiques associés à un stress psychologique chronique. Par comparaison avec l'état de la technique, l'invention concerne une application d'acide kynurénique ou d'un dérivé de celui-ci dans la préparation d'un médicament pour améliorer des dommages pathologiques associés à un stress psychologique chronique. Des recherches apparentées prouvent que l'administration orale d'acide kynurénique a un effet bénéfique dans l'amélioration d'interaction sociale altérée, de troubles inflammatoires du système nerveux central et de dysrégulation immunitaire splénique associée à un stress psychologique chronique.
(ZH)
犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用。相对于现有技术,公开了犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用,通过相关研究证实,口服给予犬尿喹啉酸有着良好的改善慢性精神应激相关社交障碍、中枢炎症紊乱、脾脏免疫失调的作用。
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Latest bibliographic data on file with the International Bureau