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1. WO2020088194 - HETEROCYCLIC AMIDE FOR INHIBITING RIP1 KINASE AND USES THEREOF

Publication Number WO/2020/088194
Publication Date 07.05.2020
International Application No. PCT/CN2019/109899
International Filing Date 08.10.2019
IPC
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 413/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/553 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
553having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants
  • 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN]/[CN]
Inventors
  • 周兵 ZHOU, Bing
  • 唐炜 TANG, Wei
  • 杨向波 YANG, Xiangbo
  • 路慧敏 LU, Huimin
  • 高梦颖 GAO, Mengying
  • 杨亚玺 YANG, Yaxi
  • 冯慧瑾 FENG, Huijin
Agents
  • 北京金信知识产权代理有限公司 KINGSOUND & PARTNERS
Priority Data
201811301267.902.11.2018CN
201910712428.102.08.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HETEROCYCLIC AMIDE FOR INHIBITING RIP1 KINASE AND USES THEREOF
(FR) AMIDE HÉTÉROCYCLIQUE INHIBANT LA KINASE RIP1 ET SES APPLICATIONS
(ZH) 抑制RIP1激酶的杂环酰胺及其用途
Abstract
(EN)
The present invention relates to a heterocyclic amide for inhibiting RIP1 kinase and the uses thereof, and specifically relates to a compound represented by the general formula (I), a pharmaceutically acceptable salt, a stereoisomer, an enantiomer and a diastereoisomer, a transisomer, an optical isomer, a racemate, a polymorph, a solvent compound or an isotope-labeled compound, a pharmaceutical composition containing the compound and the pharmaceutical uses thereof. The compound is particularly effective for treating diseases mediated by the RIP1 kinase.
(FR)
La présente invention concerne un amide hétérocyclique inhibant la kinase RIP1 et ses applications, et se rapporte particulièrement à un composé de formule générale (I), son sel pharmaceutiquement acceptable, son stéré-oisomère, son énantiomère et son diastéréo-isomère, son transisomère, son isomère optique, son racémate, son polymorphe, son composé solvant, et une composition contenant le composé et son sel pharmaceutiquement acceptable. Le composé est particulièrement indiqué pour le traitement des maladies induites par la kinase RIP1.
(ZH)
一种抑制RIP1激酶的杂环酰胺及其用途,特别涉及一种由通式(I)表示的化合物、其可药用的盐、立体异构体、对映异构体、非对映异构体、阻转异构体、光学异构体、外消旋体、多晶型物、溶剂合物或经同位素标记之化合物,包含该化合物的药物组合物及其制药用途。化合物对RIP1激酶介导的疾病或病症的治疗特别有效。
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