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1. WO2020087760 - MARKER OF FETAL TROPHOBLAST CELL, IDENTIFICATION METHOD, DETECTION KIT AND USE THEREOF

Publication Number WO/2020/087760
Publication Date 07.05.2020
International Application No. PCT/CN2018/125798
International Filing Date 29.12.2018
IPC
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C12N 5/073 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
073Embryonic cells or tissues; Foetal cells or tissues
Applicants
  • 苏州浚惠生物科技有限公司 SUZHOU JUNHUI BIOTECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 施奇惠 SHI, Qihui
  • 王春英 WANG, Chunying
Agents
  • 上海思微知识产权代理事务所(普通合伙) SHANGHAI SAVVY INTELLECTUAL PROPERTY AGENCY
Priority Data
201811290842.X31.10.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MARKER OF FETAL TROPHOBLAST CELL, IDENTIFICATION METHOD, DETECTION KIT AND USE THEREOF
(FR) MARQUEUR DE CELLULE TROPHOBLASTIQUE FOETALE, PROCÉDÉ D'IDENTIFICATION, KIT DE DÉTECTION ET UTILISATION CORRESPONDANTE
(ZH) 胎儿滋养层细胞的标志物、鉴定方法、检测试剂盒和应用
Abstract
(EN)
A marker of fetal trophoblast cells, an identification method, a detection kit and the use thereof. The identification method comprises performing dyeing treatment on a sample containing fetal trophoblast cells with a fluorescence-labeled HK2 antibody substance, and then performing fluorescence detection, wherein HK2 positive cells are target cells. The kit comprises a fluorescence-labeled HK2 antibody substance and a cell nucleus dye. The above-mentioned technical solution can sensitively and reliably detect fetal trophoblast cells in the cervical mucus or blood samples of pregnant women in the first trimester, and especially can be used for prenatal diagnosis in early pregnancy.
(FR)
Marqueur de cellules trophoblastiques foetales, procédé d'identification, kit de détection et utilisation correspondante. Le procédé d'identification consiste à effectuer un traitement de coloration sur un échantillon contenant des cellules trophoblastiques foetales avec une substance d'anticorps HK2 marquée par fluorescence, puis à effectuer une détection de fluorescence, les cellules positives à HK2 étant des cellules cibles. Le kit comprend une substance d'anticorps HK2 marquée par fluorescence et un colorant de noyau cellulaire. La solution technique susmentionnée peut détecter de manière sensible et fiable des cellules trophoblastiques foetales dans le mucus cervical ou des échantillons sanguins de femmes enceintes dans le premier trimestre, et peut notamment être utilisée pour un diagnostic prénatal en grossesse précoce.
(ZH)
一种胎儿滋养层细胞的标志物、鉴定方法、检测试剂盒和应用。所述鉴定方法是采用用荧光标记的HK2抗体物质对含有胎儿滋养层细胞的样本进行染色处理,然后进行荧光检测,若HK2阳性的细胞就是目标细胞。所述试剂盒包括荧光标记的HK2抗体物质和细胞核染色剂。上述技术方案能够在孕早期妇女的宫颈粘液样本或血液样本中,较为灵敏可靠地检测到胎儿滋养层细胞,尤其可用于孕早期产前诊断。
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