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1. WO2020076954 - ANTIBODIES DIRECTED TO FILAMIN-A AND THERAPEUTIC USES THEREOF

Publication Number WO/2020/076954
Publication Date 16.04.2020
International Application No. PCT/US2019/055401
International Filing Date 09.10.2019
IPC
A61K 51/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
08Peptides, e.g. proteins
10Antibodies or immunoglobulins; Fragments thereof
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/80
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
A61K 2039/812
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
812Breast
A61K 2039/86
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
86Lung
A61K 2039/884
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
884prostate
A61K 47/62
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
Applicants
  • IBEX BIOSCIENCES, LLC [US]/[US]
Inventors
  • KARLIN, Michael Joseph
  • CROCI, Alberto Murat
  • DE LA CRUZ, Vidal Felix
  • LAI, Norman Zhennan
  • FEINSON, Roy
Agents
  • VEITENHEIMER, Erich
  • TEAGUE, Meghann
  • HOLLY, David
Priority Data
62/743,16909.10.2018US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES DIRECTED TO FILAMIN-A AND THERAPEUTIC USES THEREOF
(FR) ANTICORPS DIRIGÉS CONTRE LA FILAMINE-A ET LEURS UTILISATIONS THÉRAPEUTIQUES
Abstract
(EN) The disclosure teaches antibodies that are useful, inter alia, in methods for detecting and treating human cancer. In a particular aspect, the disclosure teaches novel antibodies that are useful for detecting and treating human breast cancer. In some embodiments, the disclosure teaches novel antibodies that bind to filamin A. In some embodiments, the antibodies are intrabodies.
(FR) L'invention concerne des anticorps qui sont utiles, entre autres, dans des méthodes de détection et de traitement du cancer humain. Dans un aspect particulier, l'invention concerne de nouveaux anticorps qui sont utiles pour détecter et traiter le cancer du sein humain. Dans certains modes de réalisation, l'invention concerne de nouveaux anticorps qui se lient à la filamine A, et dans certains modes de réalisation, les anticorps sont des intracorps.
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