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1. WO2020072993 - HMGB1 PROTEIN DERIVATIVES FOR THE REMOVAL OF BIOFILMS CROSS-REFERENCE TO RELATED APPLICATION

Publication Number WO/2020/072993
Publication Date 09.04.2020
International Application No. PCT/US2019/054851
International Filing Date 04.10.2019
IPC
A61P 37/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/1232
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
12against material from bacteria
1203from Gram-negative bacteria
1228from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
1232from Escherichia (G)
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applicants
  • RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL [US]/[US]
Inventors
  • GOODMAN, Steven, David
  • BAKALETZ, Lauren, Opremcak
Agents
  • KONSKI, Antoinette, F.
  • DIEZ, Peter
  • SHELTON, Daniel, R.
  • LIU, Cliff, Z.
  • DANIELSON, Mark, J.
Priority Data
62/742,10205.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HMGB1 PROTEIN DERIVATIVES FOR THE REMOVAL OF BIOFILMS CROSS-REFERENCE TO RELATED APPLICATION
(FR) DÉRIVÉS DE PROTÉINE HMGB1 POUR L'ÉLIMINATION DE BIOFILMS RENVOYANT À UNE DEMANDE CONNEXE
Abstract
(EN)
Provided herein are derivatives of HMGB1 that have been engineered to possess the same efficacious anti-bio film activity but are smaller and do not induce inflammation.
(FR)
La présente invention concerne des dérivés de HMGB1 qui ont été modifiés pour posséder la même activité antibiofilm efficace mais qui sont plus petits et n'induisent pas d'inflammation.
Latest bibliographic data on file with the International Bureau