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1. WO2020072821 - IL-12 HETERODIMERIC FC-FUSION PROTEINS

Publication Number WO/2020/072821
Publication Date 09.04.2020
International Application No. PCT/US2019/054570
International Filing Date 03.10.2019
IPC
C07K 14/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
A61K 38/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/5434
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
5434IL-12
C07K 2319/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applicants
  • XENCOR, INC. [US]/[US]
Inventors
  • BERNETT, Matthew
  • DESJARLAIS, John, R.
  • VARMA, Rajat
  • LIU, Ke
  • HASSANZADEH-KIABI, Nargess
  • RASHID, Rumana
Agents
  • NG, Jennifer, K.
  • MACDOUGALL, Christina
  • TALUKDER, Gargi
  • MANN, Jeffry, S.
  • ANTCZAK, Andrew
Priority Data
62/740,81303.10.2018US
62/810,03825.02.2019US
62/848,51215.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IL-12 HETERODIMERIC FC-FUSION PROTEINS
(FR) PROTÉINES DE FUSION FC HÉTÉRODIMÈRES D'IL -12
Abstract
(EN)
The present invention provides novel IL-12 Fc fusion proteins, methods of making and using the same. The IL-12 Fc fusion proteins are useful for treatment of cancer and can be used in combination with checkpoint blockade.
(FR)
L'invention porte sur des dispositifs endovasculaires et sur des méthodes de production et d'utilisation de ceux-ci. Les protéines de fusion Fc d'IL-12 sont utiles pour le traitement du cancer et peuvent être utilisées en combinaison avec un blocage de points de contrôle.
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