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1. WO2020072608 - COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY NEUROLOGICAL DISORDERS

Publication Number WO/2020/072608
Publication Date 09.04.2020
International Application No. PCT/US2019/054245
International Filing Date 02.10.2019
IPC
A61K 38/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07K 14/575 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
CPC
A61K 31/423
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61K 38/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
C07K 14/70596
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere
Applicants
  • GEORGETOWN UNIVERSITY [US]/[US]
Inventors
  • HUANG, Jeffrey
  • BAYDYUK, Maryna
Agents
  • GARMAN, Russell, A.
Priority Data
62/740,17502.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY NEUROLOGICAL DISORDERS
(FR) COMPOSITIONS ET MÉTHODES POUR TRAITER DES TROUBLES NEUROLOGIQUES INFLAMMATOIRES
Abstract
(EN)
The present application is directed to methods and compositions for treating a condition marked by enhanced inflammation in the central nervous system (CNS). The methods comprise administering to a subject in need of treatment of enhanced inflammation in the CNS an inhibitor of an amino acid transporter in inflammatory cells present in the CNS. The compositions of the present invention relate to compositions comprising an inhibitor of an amino acid transporter in inflammatory cells, or a pharmaceutically acceptable salt thereof, wherein the composition is formulated for direct administration into the CNS of a mammal.
(FR)
La présente invention concerne des procédés et des compositions pour traiter un état marqué par une inflammation exacerbée dans le système nerveux central (SNC). Les procédés comprennent l'administration d'un inhibiteur de transporteur d'acides aminés dans des cellules inflammatoires présentes dans le SNC d'un sujet nécessitant un traitement d'une inflammation exacerbée dans le SNC. La présente invention concerne des compositions comprenant un inhibiteur de transporteur d'acides aminés dans des cellules inflammatoires, ou un sel pharmaceutiquement acceptable de celui-ci, la composition étant formulée pour une administration directe dans le SNC d'un mammifère.
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