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1. WO2020072538 - INHIBITORS OF P-TEFB MEDIATED TRANSCRIPTION

Publication Number WO/2020/072538
Publication Date 09.04.2020
International Application No. PCT/US2019/054134
International Filing Date 01.10.2019
IPC
C07K 14/005 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
  • PETERLIN, Boris [US]/[US]
Inventors
  • PETERLIN, Boris
  • FUJINAGA, Koh
  • LEOZ, Marie
Agents
  • BERMAN, Matthew
Priority Data
62/739,42501.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF P-TEFB MEDIATED TRANSCRIPTION
(FR) INHIBITEURS DE LA TRANSCRIPTION À MÉDIATION PAR P-TEFB
Abstract
(EN)
Novel chimeric proteins may be used to inhibit transcriptional activities that are mediated by transcription factor interactions with P-TEFb. The chimeras contain elements that recruit the target transcription factor, maintain CDK9 in an inactive state, and competitively inhibit P-TEFb binding to the transcription factor. The chimeras may be configured for inhibition of HIV Tat mediated transcription and thus provide a novel means of preventing reactivation of integrated HIV, providing a new tool for emerging "block and lock" HIV cure strategies.
(FR)
La présente invention concerne de nouvelles protéines chimères qui peuvent être utilisées pour inhiber des activités transcriptionnelles à médiation par des interactions du facteur de transcription avec P-TEFb. Les protéines chimères contiennent des éléments de recrutement du facteur de transcription cible, maintiennent CDK9 dans un état inactif, et inhibent de manière compétitive la liaison P-TEFb au facteur de transcription. Les protéines chimères peuvent être configurées pour inhiber la transcription à médiation par VIH Tat et fournir ainsi un nouveau moyen de prévention de la réactivation du VIH intégré, ce qui permet d'obtenir un nouvel outil pour des stratégies de traitement du VIH "block and lock".
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