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1. WO2020072248 - RECOMBINANT TYPE I CRISPR-CAS SYSTEM

Publication Number WO/2020/072248
Publication Date 09.04.2020
International Application No. PCT/US2019/052861
International Filing Date 25.09.2019
IPC
C12N 15/74 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
C12N 15/00 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C07H 21/04 2006.01
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07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
CPC
C12N 15/102
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
102Mutagenizing nucleic acids
C12N 15/11
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12N 15/90
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90Stable introduction of foreign DNA into chromosome
C12N 2310/20
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2310Structure or type of the nucleic acid
10Type of nucleic acid
20involving clustered regularly interspaced short palindromic repeats [CRISPRs]
C12N 9/22
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9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
16acting on ester bonds (3.1)
22Ribonucleases ; RNAses, DNAses
C40B 40/06
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40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
06Libraries containing nucleotides or polynucleotides, or derivatives thereof
Applicants
  • NORTH CAROLINA STATE UNIVERSITY [US]/[US]
Inventors
  • BARRANGOU, Rodolphe
  • CANTABRANA, Claudio Hidalgo
Agents
  • BONNEN, Alice M.
Priority Data
62/739,66601.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RECOMBINANT TYPE I CRISPR-CAS SYSTEM
(FR) SYSTÈME CRISPR-CAS DE TYPE I RECOMBINANT
Abstract
(EN)
This invention relates to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type l-E CASCADE complexes as well as plasmids, retroviruses and bacteriophage comprising the same. Specifically, the CRISPR array comprising two or more repeat sequences and one or more spacer sequence(s). Further disclosed are repeat nucleotide sequences.
(FR)
L'invention concerne des réseaux de courtes répétitions palindromiques groupées et régulièrement espacées (CRISPR) et des constructions d'acides nucléiques de recombinaison codant pour des complexes CASCADE de type I-E, ainsi que des plasmides, des rétrovirus et des bactériophages comprenant ceux-ci. En particulier, le réseau CRISPR comprend au moins deux séquences de répétition et au moins une séquence d'espacement. L'invention concerne également des séquences de nucléotide de répétition.
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