Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020072169 - HIV-1 ENVELOPE STABILIZING MUTATIONS

Publication Number WO/2020/072169
Publication Date 09.04.2020
International Application No. PCT/US2019/049662
International Filing Date 05.09.2019
IPC
A61K 39/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07H 21/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/162
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
16HIV-1 ; ; HIV-2
162env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
Applicants
  • DUKE UNIVERSITY [US]/[US]
Inventors
  • HENDERSON, Rory
  • ALAM, S., Munir
  • HAYNES, Barton, F
  • WIEHE, Kevin, J.
Agents
  • KIM, William, W.
  • BLAKELY, Lauren
  • BERTULLI, Scott
  • ANDERSON, Thomas, E.
  • BEVILACQUA, Michael, J.
Priority Data
62/739,72701.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HIV-1 ENVELOPE STABILIZING MUTATIONS
(FR) MUTATIONS STABILISANT L'ENVELOPPE DU VIH-1
Abstract
(EN)
The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV envelope. Specifically, the disclosure provides recombinant HIV-1 Env proteins comprising mutations, wherein the envelope is a protomer, and wherein three protomers form a trimer stabilized by the presence of the mutations. Provided also are compositions comprising envelopes of the technology, and methods of use.
(FR)
La technologie concerne des enveloppes du VIH qui comprennent des modifications de séquences, ces modifications empêchant les transitions induites par le CD4 de l'enveloppe du VIH. Plus particulièrement, l'invention concerne des protéines d'enveloppe recombinées du VIH-1 comprenant des mutations, l'enveloppe étant un protomère, et les trois protomères forment un trimère stabilisé en présence des mutations. L'invention concerne également des compositions comprenant des enveloppes selon la technologie et des méthodes d'utilisation.
Latest bibliographic data on file with the International Bureau