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1. WO2020071931 - METHOD FOR THE PRODUCTION OF A VISCOELASTIC GEL SUPPLEMENTING THE SYNOVIAL FLUID AND A VISCOELASTIC GEL SUPPLEMENTING SYNOVIAL FLUID

Publication Number WO/2020/071931
Publication Date 09.04.2020
International Application No. PCT/PL2019/000082
International Filing Date 20.09.2019
IPC
A61L 27/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
16obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
20Polysaccharides
A61L 27/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
26Mixtures of macromolecular materials
A61L 27/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
A61L 27/52 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
52Hydrogels or hydrocolloids
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
CPC
A61L 2300/102
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
10containing or releasing inorganic materials
102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
A61L 2300/104
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
10containing or releasing inorganic materials
102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
104Silver, e.g. silver sulfadiazine
A61L 2300/404
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
404Biocides, antimicrobial agents, antiseptic agents
A61L 2400/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
06Flowable or injectable implant compositions
A61L 2400/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
10Materials for lubricating medical devices
A61L 27/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
16obtained by reactions only involving carbon-to-carbon unsaturated bonds
Applicants
  • DOLNIAK, Błażej [PL]/[PL]
  • ZAKRZEWSKA, Barbara [PL]/[PL]
Inventors
  • DOLNIAK, Błażej
  • ZAKRZEWSKA, Barbara
Common Representative
  • ZAKRZEWSKA, Barbara
Priority Data
P.42732201.10.2018PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR THE PRODUCTION OF A VISCOELASTIC GEL SUPPLEMENTING THE SYNOVIAL FLUID AND A VISCOELASTIC GEL SUPPLEMENTING SYNOVIAL FLUID
(FR) PROCÉDÉ DE PRODUCTION D'UN GEL VISCOÉLASTIQUE COMPLÉTANT LE LIQUIDE SYNOVIAL ET GEL VISCOÉLASTIQUE COMPLÉTANT LE LIQUIDE SYNOVIAL
Abstract
(EN)
The subject of the invention is a method for the production of a viscoelastic gel supplementing the synovial fluid and a viscoelastic gel supplementing synovial fluid, which is widely used in veterinary medicine for alleviating the symptoms of joint dysfunction by increasing the slip on the surface of connective tissue. The essence of the method is that the aqueous polymer solution with an average molecular weight above 1500 Da and a concentration of 0.1% to 40% by weight, preferably polyvinylpyrrolidone and/or polyvinyl alcohol and/or hyaluronic acid, is mixed with aqueous gold colloid solution of 0.001% to 0.04% by weight and/or aqueous silver colloid solution of 0.001% to 0.04% by weight, with one part by volume of aqueous polymer solution being mixed for at least 15 minutes with one to four parts by volume of aqueous gold and/or silver colloid solution. The viscous-elastic gel contains water in which the polymer with an average molecular weight above 1500 Da is dissolved in an amount of 0.08% by weight to 26.6% by weight, preferably polyvinylpyrrolidone and/or polyvinyl alcohol and/or hyaluronic acid and colloidal gold in an amount of 0.0025% by weight to 0.01% by weight and/or colloidal silver in an amount of 0.00025% by weight to 0.01% by weight.
(FR)
L'invention a pour objet un procédé de production d'un gel viscoélastique complétant le liquide synovial et un gel viscoélastique complétant le liquide synovial, qui est largement utilisé en médecine vétérinaire pour soulager les symptômes d'un dysfonctionnement articulaire en augmentant le glissement sur la surface du tissu conjonctif. L'essence du procédé est que la solution aqueuse de polymère ayant un poids moléculaire moyen supérieur à 1 500 Da et une concentration de 0,1 % à 40 % en poids, de préférence de la polyvinylpyrrolidone et/ou de l'alcool polyvinylique et/ou de l'acide hyaluronique, est mélangée avec une solution aqueuse colloïdale d'or de 0,001 % à 0,04 % en poids et/ou avec une solution aqueuse colloïdale d'argent de 0,001 % à 0,04 % en poids, avec une partie en volume de solution aqueuse de polymère étant mélangée pendant au moins 15 minutes avec une à quatre parties en volume d'une solution aqueuse d'or et/ou de colloïde d'argent. Le gel visqueux-élastique contient de l'eau dans laquelle le polymère ayant un poids moléculaire moyen supérieur à 1 500 Da est dissous dans une quantité de 0,08 % en poids à 26,6 % en poids, de préférence de la polyvinylpyrrolidone et/ou de l'alcool polyvinylique et/ou de l'acide hyaluronique et de l'or colloïdal en une quantité de 0,0025 % en poids à 0,01 % en poids et/ou de l'argent colloïdal en une quantité de 0,00025 % en poids à 0,01 % en poids.
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