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1. WO2020071279 - METHOD FOR ASSISTING PREDICTION OF SHUNT TROUBLE AND KIT THEREFOR

Publication Number WO/2020/071279
Publication Date 09.04.2020
International Application No. PCT/JP2019/038209
International Filing Date 27.09.2019
IPC
C12Q 1/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
26involving oxidoreductase
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
G01N 33/49 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
49blood
CPC
A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
C12Q 1/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
26involving oxidoreductase
G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
483Physical analysis of biological material
487of liquid biological material
49Blood
Applicants
  • 旭化成ファーマ株式会社 ASAHI KASEI PHARMA CORPORATION [JP]/[JP]
  • 独立行政法人地域医療機能推進機構 JAPAN COMMUNITY HEALTH CARE ORGANIZATION [JP]/[JP]
Inventors
  • 松岡 毅 MATSUOKA, Takeshi
  • 植田 成 UEDA, Shigeru
  • 眞田 覚 SANADA, Satoru
  • 神田 学 KANDA, Manabu
  • 北村 洋 KITAMURA, Hiroshi
Agents
  • 稲葉 良幸 INABA, Yoshiyuki
  • 大貫 敏史 ONUKI, Toshifumi
  • 内藤 和彦 NAITO, Kazuhiko
Priority Data
2018-18693201.10.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR ASSISTING PREDICTION OF SHUNT TROUBLE AND KIT THEREFOR
(FR) PROCÉDÉ D'AIDE À LA PRÉDICTION D'UN PROBLÈME DE SHUNT ET KIT ASSOCIÉ
(JA) シャントトラブル予測の補助方法およびそのためのキット
Abstract
(EN)
Provided is a method for assisting the prediction of the likelihood of the occurrence of a shunt trouble, said method comprising a step for, when the mevalonic acid concentration in a sample derived from a patient undergoing hemodialysis is equal to or higher than a preset cutoff value or the mevalonic acid concentration increases with time, then predicting that the shunt trouble highly likely occurs.
(FR)
L'invention concerne un procédé d'aide à la prédiction de la probabilité d'apparition d'un problème de shunt, ledit procédé comprenant une étape consistant à, lorsque la concentration d'acide mévalonique dans un échantillon provenant d'un patient subissant une hémodialyse est égale ou supérieure à une valeur seuil prédéfinie ou que la concentration d'acide mévalonique augmente avec le temps, alors prédire que le problème de shunt se produit très probablement.
(JA)
本発明は、シャントトラブルの起こりやすさの予測を補助する方法であって、血液透析患者由来のサンプル中のメバロン酸濃度が、予め設定されたカットオフ値以上である場合か、あるいは、メバロン酸濃度が経時的に増大する場合に、シャントトラブルが起こりやすいと決定する工程を含む、方法、を提供する。
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