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1. WO2020071258 - PROTEIN GLYCATION SUPPRESSANT

Publication Number WO/2020/071258
Publication Date 09.04.2020
International Application No. PCT/JP2019/038055
International Filing Date 26.09.2019
IPC
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61K 8/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
34Alcohols
A61K 8/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts, esters or N-acylated derivatives thereof
A61K 8/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
46containing sulfur
A61K 8/49 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 31/405 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 31/405
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A61K 33/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
18Iodine; Compounds thereof
A61K 38/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 8/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
34Alcohols
Applicants
  • 味の素株式会社 AJINOMOTO CO., INC. [JP]/[JP]
Inventors
  • ビスワス シュヴェンドゥ BISWAS, Shuvendu
  • 桐生 翔一朗 KIRYU, Shoichiro
Agents
  • 特許業務法人酒井国際特許事務所 SAKAI INTERNATIONAL PATENT OFFICE
Priority Data
2018-18836803.10.2018JP
2019-00213209.01.2019JP
2019-07263105.04.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROTEIN GLYCATION SUPPRESSANT
(FR) SUPPRESSEUR DE GLYCATION DE PROTÉINE
(JA) タンパク質糖化抑制剤
Abstract
(EN)
The present invention addresses the problem of providing a composition, etc., that has an exceptional antiglycation function. In particular, the present invention: provides a component that exhibits an antiglycation function against a wide range of advanced glycation end products, is unlikely to discolor even when used in cosmetics, etc., while having an antioxidant function, and has high safety and biocompatibility; and provides a composition, etc., containing a component that exhibits an antiglycation function against a wide range of advanced glycation end products, and is highly stable, safe, and biocompatible while having an antioxidant function. The present invention provides a protein glycation suppressant characterized by containing, as an active ingredient, a C3 or higher neutral amino acid or a salt thereof, and also provides a protein glycation suppressant characterized by containing, as an active ingredient: a dipeptide which has an amino acid selected from the group consisting of acidic amino acids, basic amino acids, hydroxyamino acids, branched amino acids, and antioxidant amino acids as a constituent amino acid, and in which the constituent amino acid on the C-end side is an antioxidant amino acid; or a salt thereof.
(FR)
La présente invention concerne le problème consistant à fournir une composition, etc., qui présente une fonction exceptionnelle antiglycation. En particulier, la présente invention : fournit un constituant qui fait preuve d’une fonction antiglycation contre une large plage de produits finaux avancés de glycation, n’est pas susceptible de se décolorer même lorsque celui-ci est employé dans les produits cosmétiques, etc., tout en ayant une fonction antioxydante, et présente une sécurité et une biocompatibilité élevées ; et fournit une composition, etc., contenant un constituant qui fait preuve d’une fonction antiglycation contre une large plage de produits finaux avancés de glycation, et est fortement stable, sécure, et biocompatible tout en ayant une fonction antioxydante. La présente invention fournit un suppresseur de glycation de protéine caractérisé en ce qu’il contient, en tant qu'ingrédient actif, un acide aminé neutre en C3 ou supérieur ou un sel de celui-ci, et fournit également un suppresseur de glycation de protéine caractérisé en ce que celui-ci contient, en tant qu'ingrédient actif : un dipeptide qui possède un acide aminé sélectionné dans le groupe constitué des acides aminés acides, des acides aminés basiques, des acides hydroxyamino, des acides aminés ramifiés, et des acides aminés antioxydants en tant qu'acide aminé constitutif, et dans lequel l’acide aminé constitutif sur le côté d’extrémité C est un acide aminé antioxydant ; ou un sel de celui-ci.
(JA)
本発明の課題は、優れた抗糖化機能を示す組成物等を提供する。特に、幅広い終末糖化産物に対して抗糖化機能を示し、さらに抗酸化機能を有しつつ、化粧料等に使用しても着色し難く、安全性・生体適合性の高い成分を提供すること、幅広い終末糖化産物に対して抗糖化機能を示し、さらに抗酸化機能を有しつつ、安定性、安全性、生体適合性の高い成分を含む組成物等を提供すること。本発明は、炭素原子数が3以上の中性アミノ酸又はその塩を有効成分として含有することを特徴とするタンパク質糖化抑制剤、並びに酸性アミノ酸、塩基性アミノ酸、ヒドロキシアミノ酸、分岐鎖アミノ酸、及び抗酸化性のアミノ酸からなる群から選ばれるアミノ酸を構成アミノ酸とし、且つC末端側の構成アミノ酸が、抗酸化性のアミノ酸であるジペプチド又はその塩を有効成分として含有することを特徴とするタンパク質糖化抑制剤。
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