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1. WO2020070053 - USE OF INHIBITORS OF STRESS GRANULE FORMATION FOR TARGETING THE REGULATION OF IMMUNE RESPONSES

Publication Number WO/2020/070053
Publication Date 09.04.2020
International Application No. PCT/EP2019/076414
International Filing Date 30.09.2019
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 31/7105 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61K 31/7105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]/[FR]
  • UNIVERSITÉ PAUL SABATIER TOULOUSE III [FR]/[FR]
Inventors
  • FOURNIE, Jean-Jacques
  • FRANCHINI, Don-Marc
  • LANVIN, Olivia
  • MILLEVOI, Stefania
Agents
  • PLASSERAUD
Priority Data
18306286.801.10.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF INHIBITORS OF STRESS GRANULE FORMATION FOR TARGETING THE REGULATION OF IMMUNE RESPONSES
(FR) UTILISATION D'INHIBITEURS DE FORMATION DE GRANULES DE STRESS POUR CIBLER LA RÉGULATION DE RÉPONSES IMMUNITAIRES
Abstract
(EN)
The mechanisms of tumor escape are numerous, but the immunosuppressive action of coinhibitory molecules has emerged this last decade as the most attractive one for imaging new treatments of cancer. Activation of lymphocytes is indeed regulated by both costimulatory and coinhibitory molecules also called "immune checkpoints". Now the inventors show that T cell activation triggers mRNA and protein expression of stress granule components and more particularly show that immune checkpoint mRNA interact with said stress granules. More importantly, stress granule inhibitors impair expression of immune checkpoint and thus represent an attractive target for targeting the regulation of immune response.
(FR)
Les mécanismes d'échappement tumoral sont nombreux, mais l'action immunosuppressive des molécules co-inhibitrices est apparue ces dix dernières années comme la plus intéressante pour l'imagerie de nouveaux traitements du cancer. L'activation des lymphocytes est en effet régulée par des molécules costimulantes et co-inhibitrices également appelées "points de contrôle immunitaires". Les inventeurs ont maintenant démontré que l'activation des cellules T déclenche l'expression de l'ARNm et des protéines des composants de granules de stress et montrent plus particulièrement que l'ARNm de points de contrôle immunitaires interagit avec lesdits granules de stress. De manière plus importante, les inhibiteurs de granules de stress affectent l'expression du point de contrôle immunitaire et représentent ainsi une cible attractive pour cibler la régulation de la réponse immunitaire.
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