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1. WO2020069397 - METHODS FOR DETECTION OF MICROBIAL NUCLEIC ACIDS IN BODY FLUIDS

Publication Number WO/2020/069397
Publication Date 02.04.2020
International Application No. PCT/US2019/053586
International Filing Date 27.09.2019
IPC
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C12P 19/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
CPC
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
Applicants
  • CORTEXYME, INC. [US]/[US]
Inventors
  • RAHA, Debasish
  • HOLSINGER, Leslie J.
  • DOMINY, Stephen S.
  • LYNCH, Casey C.
Agents
  • PRESLEY, Andrew D.
  • GARRETT-WACKOWSKI, Eugenia
Priority Data
62/737,74927.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR DETECTION OF MICROBIAL NUCLEIC ACIDS IN BODY FLUIDS
(FR) PROCÉDÉS DE DÉTECTION D'ACIDES NUCLÉIQUES MICROBIENS DANS DES FLUIDES CORPORELS
Abstract
(EN)
Methods for detecting microbial nucleic acids in a body fluid of a subject are provided. The methods include highly sensitive and specific procedures for detecting DNA derived from the bacteria such as Porphyromonas gingivalis, e.g., using PCR amplification and qPCR detection, in clinical and/or laboratory samples containing CSF or other biofluids.
(FR)
L'invention concerne des procédés de détection d'acides nucléiques microbiens dans un fluide corporel d'un sujet. Les procédés comprennent des procédés hautement sensibles et spécifiques pour détecter l'ADN issu des bactéries telles que Porphyromonas gingivalis, par exemple à l'aide d'une amplification par PCR et d'une détection par qPCR, dans des échantillons cliniques et/ou de laboratoire contenant du LCR ou d'autres biofluides.
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