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1. WO2020069319 - COMPOSITIONS AND METHODS FOR USE OF CXCL 12 IN TREATMENT OF BONE DISORDERS

Publication Number WO/2020/069319
Publication Date 02.04.2020
International Application No. PCT/US2019/053463
International Filing Date 27.09.2019
IPC
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
Applicants
  • NEW YORK UNIVERSITY [US]/[US]
  • UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US]/[US]
Inventors
  • CASTILLO, Alesha
  • MONTCLARE, Jin, Kim
  • PUNIA, Kamia
Agents
  • SLAUGHTER, Alison
  • ALLEN, Justin
  • ARTIS, Ryan
  • CHEN, Ming
  • ALLEN, Scott, E.
Priority Data
62/737,16427.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR USE OF CXCL 12 IN TREATMENT OF BONE DISORDERS
(FR) COMPOSITIONS ET PROCÉDÉS D'UTILISATION DE CXCL12 DANS LE TRAITEMENT DE LÉSIONS OSSEUSES
Abstract
(EN)
The present invention provides compositions and methods for treating a disease or disorder associated with bone defects or reduced o abnormal bone formation. In one embodiment, the method comprises administering to the subject a composition comprising a modulat of CXCL12. In one embodiment, the modulator of CXCL12 is at least one selected from the group consisting of a chemical compound, protein, a peptide, a peptidomemetic, an antibody, a ribozyme, a small molecule chemical compound, a nucleic acid, a vector, and an antisense nucleic acid molecule.
(FR)
La présente invention concerne des compositions et des méthodes de traitement d'une maladie ou d'un trouble associé à des défauts osseux ou une formation osseuse réduite ou anormale. Dans un mode de réalisation, la méthode comprend l'administration au sujet d'une composition comprenant un modulateur de CXCL12. Dans un mode de réalisation, le modulateur de CXCL12 est au moins un élément choisi dans le groupe consistant en un composé chimique, une protéine, un peptide, un peptidomimétique, un anticorps, un ribozyme, un composé chimique à petite molécule, un acide nucléique, un vecteur et une molécule d'acide nucléique anti-sens.
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