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1. WO2020069285 - LIVER SUPPORT SYSTEM COMPRISING LIVER ORGANOIDS AND METHODS OF MAKING AND USING SAME

Publication Number WO/2020/069285
Publication Date 02.04.2020
International Application No. PCT/US2019/053408
International Filing Date 27.09.2019
IPC
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
C12N 5/071 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
C12M 1/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
12with sterilisation, filtration, or dialysis means
CPC
A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
C12M 25/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
25Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
14Scaffolds; Matrices
Applicants
  • CHILDREN'S HOSPITAL MEDICAL CENTER [US]/[US]
Inventors
  • TAKEBE, Takanori
  • BEZERRA, Jorge A.
Agents
  • TEPE, Nicole, M.
  • GOLDSTEIN, Steven, J.
  • SCHOEN, Ann, G.
  • CONLEY, Scott, R.
  • ACHESON, JR., Edwin, R.
Priority Data
62/737,26127.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIVER SUPPORT SYSTEM COMPRISING LIVER ORGANOIDS AND METHODS OF MAKING AND USING SAME
(FR) SYSTÈME DE SUPPORT DU FOIE COMPRENANT DES ORGANOÏDES DU FOIE ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CELUI-CI
Abstract
(EN)
Disclosed herein are bioartificial liver systems ("BAL"or "liver assist device") that employ liver organoids. The disclosed systems may be used to provide a therapeutic benefit to an individual in need thereof, particularly an individual having compromised liver function. The systems may include an in vivo or ex vivo component, wherein a liver function is provided to the individual using the disclosed systems.
(FR)
L'invention concerne des systèmes de foie bioartificiels ("BAL" ou "dispositif d'assistance hépatique") qui utilisent des organoïdes du foie. Les systèmes décrits peuvent être utilisés pour fournir un effet thérapeutique bénéfique à un individu qui en a besoin, en particulier un individu ayant une fonction hépatique compromise. Les systèmes peuvent comprendre un composant in vivo ou ex vivo, une fonction hépatique étant fournie à l'individu à l'aide des systèmes décrits.
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