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1. WO2020069267 - HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME

Publication Number WO/2020/069267
Publication Date 02.04.2020
International Application No. PCT/US2019/053379
International Filing Date 27.09.2019
IPC
C07J 71/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopentahydrophenanthrene skeleton is condensed with a heterocyclic ring
CPC
C07J 71/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
71Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US]
  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS [US]/[US]
Inventors
  • VIGLIANTI, Benjamin, L.
  • BROOKS, Allen, F.
  • SCOTT, Peter, J. H.
  • THOMPSON, Stephen
  • VERHOOG, Stefan
  • GROSS, Milton, D.
  • WINTON, Wade, P.
Agents
  • DANEK, Shelley, C.
  • HANNO, Mary, T.
Priority Data
62/738,09028.09.2018US
62/841,79301.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME
(FR) ANALOGUES HALOGÉNÉS DU CHOLESTÉROL ET LEURS PROCÉDÉS DE PRÉPARATION ET LEURS MÉTHODES D'UTILISATION
Abstract
(EN)
Provided herein are halogenated cholesterol analogues, including methods of making and using the same. Also provided are methods of making radiolabeled cholesterol analogues including admixing an epoxide with a fluorine-18 source under conditions to form a radiofluorinated cholesterol analogue.
(FR)
La présente invention concerne des analogues halogénés du cholestérol, ainsi que leurs procédés de préparation et leurs méthodes d'utilisation. L'invention concerne également des procédés de préparation d'analogues radiomarqués du cholestérol consistant à mélanger un époxyde avec une source de fluor-18 dans des conditions permettant de former un analogue radiofluoré du cholestérol.
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