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1. WO2020069214 - OPTIMIZED EXPRESSION SYSTEMS FOR PRODUCING CANNABINOID SYNTHASE POLYPEPTIDES, CANNABINOIDS, AND CANNABINOID DERIVATIVES

Publication Number WO/2020/069214
Publication Date 02.04.2020
International Application No. PCT/US2019/053292
International Filing Date 26.09.2019
IPC
C12N 9/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
C12N 9/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
C12N 9/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C12N 15/52 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
CPC
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
C12N 15/52
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
88Lyases (4.)
C12N 9/93
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
93Ligases (6)
Applicants
  • DEMETRIX, INC. [US]/[US]
Inventors
  • HORWITZ, Andrew
  • D'ESPAUX, Leo
  • WONG, Jeff
  • BECTOR, Rathin
  • HJELMELAND, Anna K.
  • PLATT, Darren
  • UBERSAX, Jeff
Agents
  • MAYER, Mika R.
  • TULLY, Sarah E.
  • BOLIN, Kimberly A.
  • FLECKENSTEIN, Anne E.
Priority Data
62/736,99726.09.2018US
62/750,17824.10.2018US
62/851,55622.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OPTIMIZED EXPRESSION SYSTEMS FOR PRODUCING CANNABINOID SYNTHASE POLYPEPTIDES, CANNABINOIDS, AND CANNABINOID DERIVATIVES
(FR) SYSTÈMES D'EXPRESSION OPTIMISÉS POUR PRODUIRE DES POLYPEPTIDES DE SYNTHASE DE CANNABINOÏDES, CANNABINOÏDES ET DÉRIVÉS DE CANNABINOÏDES
Abstract
(EN)
The present disclosure provides modified host cells that produce a cannabinoid or a cannabinoid derivative and modified host cells that express a cannabinoid synthase polypeptide. The present disclosure also provides methods of synthesizing a cannabinoid or a cannabinoid derivative. Further, the present disclosure provides novel cannabinoids and cannabinoid derivatives, compositions, including pharmaceutical compositions, as well as methods, uses, compounds for use, medicaments, and compositions (including pharmaceutical compositions) for use comprising said cannabinoid and cannabinoid derivatives.
(FR)
La présente invention concerne des cellules hôtes modifiées qui produisent un cannabinoïde ou un dérivé de cannabinoïde et des cellules hôtes modifiées qui expriment un polypeptide de cannabinoïde synthase. La présente invention concerne également des procédés de synthèse d'un cannabinoïde ou d'un dérivé de cannabinoïde. En outre, la présente invention concerne de nouveaux cannabinoïdes et des dérivés de cannabinoïdes, des compositions, notamment des compositions pharmaceutiques, ainsi que des procédés, des utilisations, des composés destinés à être utilisés, des médicaments et des compositions (notamment des compositions pharmaceutiques) destinés à être utilisés comprenant lesdits cannabinoïdes et dérivés de cannabinoïdes.
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