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1. WO2020069125 - DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN

Publication Number WO/2020/069125
Publication Date 02.04.2020
International Application No. PCT/US2019/053148
International Filing Date 26.09.2019
IPC
A61K 31/4035 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
4035Isoindoles, e.g. phthalimide
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
CPC
A61K 47/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
545Heterocyclic compounds
A61K 47/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
55the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07K 5/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • GRAY, Nathanael S.
  • ZHANG, Tinghu
  • YANG, Priscilla
  • DE WISPELAERE, Melissanne
  • DU, Guangyan
Agents
  • CLARKE, Daniel W.
  • JOBSE, Bruce, D.
  • SERIO, John, C.
  • COHEN, Jerry
  • GOLDMAN, Gabriel
  • GOMES, David, W.
  • HAASAN, Shahid
  • LOPEZ, Orlando
  • MARAIA, Joseph
  • MILLS, Stephen
  • MOORE, Ronda
  • QUINN, Joseph, P.
  • SCHEPPER, Marlo
  • SORKIN, Paul
  • SUSAN, Janine
  • MCGRATH, Daniel
  • CHACLAS, George
  • COWLES, Christopher
  • EMMONS, Richard
  • FOLEY, Shawn
  • KARIMI, Pegah
Priority Data
62/738,32628.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN
(FR) AGENTS DE DÉGRADATION DE LA PROTÉINE NS3/4A DU VIRUS DE L'HÉPATITE C
Abstract
(EN)
Disclosed are bifunctional compounds (degraders) that target hepatitis C virus (HCV) NS3/4A for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat HCV infection and HCV-associated diseases or disorders.
(FR)
L'invention concerne des composés bifonctionnels (agents de dégradation) qui ciblent la NS3/4A du virus de l'hépatite C (VHC) pour la dégradation de celle-ci. L'invention concerne également des compositions pharmaceutiques contenant les agents de dégradation et des méthodes d'utilisation des composés pour traiter une infection par le VHC et des maladies ou des troubles associés au VHC.
Latest bibliographic data on file with the International Bureau