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1. WO2020069117 - DEGRADATION OF FAK OR FAK AND ALK BY CONJUGATION OF FAK AND ALK INHIBITORS WITH E3 LIGASE LIGANDS AND METHODS OF USE

Publication Number WO/2020/069117
Publication Date 02.04.2020
International Application No. PCT/US2019/053139
International Filing Date 26.09.2019
IPC
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
CPC
A61K 47/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
55the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
Inventors
  • GRAY, Nathanael S.
  • JIANG, Baishan
  • NABET, Behnam
  • ZHANG, Tinghu
  • HAO, Mingfeng
Agents
  • CLARKE, Daniel W.
  • JOBSE, Bruce, D.
  • SERIO, John, C.
  • COHEN, Jerry
  • GOLDMAN, Gabriel
  • GOMES, David, W.
  • HAASAN, Shahid
  • LOPEZ, Orlando
  • MARAIA, Joseph
  • MILLS, Stephen
  • MOORE, Ronda
  • QUINN, Joseph, P.
  • SCHEPPER, Marlo
  • SORKIN, Paul
  • SUSAN, Janine
  • MCGRATH, Daniel
  • CHACLAS, George
  • COWLES, Christopher
  • EMMONS, Richard
  • FOLEY, Shawn
  • KARIMI, Pegah
Priority Data
62/737,54227.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEGRADATION OF FAK OR FAK AND ALK BY CONJUGATION OF FAK AND ALK INHIBITORS WITH E3 LIGASE LIGANDS AND METHODS OF USE
(FR) DÉGRADATION DE FAK OU FAK ET ALK PAR CONJUGAISON D'INHIBITEURS DE FAK ET D'ALK AVEC DES LIGANDS DE LIGASE E3 ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
Disclosed are bifunctional compounds (degraders) that target FAK or FAK and ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.
(FR)
L'invention concerne des composés bifonctionnels (agents de dégradation) qui ciblent FAK ou FAK et ALK pour la dégradation. L'invention concerne également des compositions pharmaceutiques contenant les agents de dégradation et des procédés d'utilisation des composés pour traiter une maladie.
Latest bibliographic data on file with the International Bureau