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1. WO2020068984 - PRODUCTION AND ENRICHMENT OF PANCREATIC ENDOCRINE PROGENITOR CELLS

Publication Number WO/2020/068984
Publication Date 02.04.2020
International Application No. PCT/US2019/052958
International Filing Date 25.09.2019
IPC
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/39 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
39Pancreas; Islets of Langerhans
A61K 38/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
26Glucagons
CPC
A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
39Pancreas; Islets of Langerhans
A61K 38/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
26Glucagons
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • SNEDDON, Julie, Beth
  • BYRNES, Lauren, E.
  • WONG, Daniel, M.
Agents
  • MERKEL, William, K.
Priority Data
62/736,23725.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRODUCTION AND ENRICHMENT OF PANCREATIC ENDOCRINE PROGENITOR CELLS
(FR) PRODUCTION ET ENRICHISSEMENT DE CELLULES PROGÉNITRICES ENDOCRINES PANCRÉATIQUES
Abstract
(EN)
The disclosure provides methods for enriching for pancreatic endocrine progenitor cells, such as human pancreatic endocrine progenitor cells, including alpha cell progenitors, beta cell progenitors, delta cell progenitors, PP cell progenitors and epsilon cell progenitors. The disclosure provides mammalian, such as human, Fev+ pancreatic endocrine progenitor cells, including Fev+ alpha cell progenitors, Fev+ beta cell progenitors, Fev+ delta cell progenitors, Fev+ PP cell progenitors, and Fev+ epsilon cell progenitors. The disclosure further provides methods for producing or inducing such cells, including in vitro differentiation methods, and the cells so produced.
(FR)
L'invention concerne des procédés d'enrichissement de cellules progénitrices endocrines pancréatiques, telles que des cellules progénitrices endocrines pancréatiques humaines, y compris des progéniteurs de cellules alpha, des progéniteurs de cellules bêta, des progéniteurs de cellules delta, des progéniteurs de cellules PP et des progéniteurs de cellules epsilon. L'invention concerne des cellules progénitrices endocrines pancréatiques, telles que des cellules progénitrices endocrines pancréatiques humaines, Fev+, y compris des progéniteurs de cellules Fev+ alpha, des progéniteurs de cellules Fev+ bêta, des progéniteurs de cellules Fev+ delta, des progéniteurs de cellules Fev+ PP, et des progéniteurs de cellules Fev+ epsilon. L'invention concerne en outre des procédés de production ou d'induction de telles cellules, y compris des procédés de différenciation in vitro, et les cellules ainsi produites.
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