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1. WO2020068854 - AMINOPYRIMIDINE COMPOUND

Publication Number WO/2020/068854
Publication Date 02.04.2020
International Application No. PCT/US2019/052730
International Filing Date 24.09.2019
IPC
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
C07D 239/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
A61P 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
CPC
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
C07D 498/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
08Bridged systems
Applicants
  • CARDURION PHARMACEUTICALS, LLC [US]/[US]
Inventors
  • MATSUNAGA, Nobuyuki
  • MIYAMOTO, Yasufumi
  • SHIRAI, Junya
  • NAKAHATA, Takashi
  • SHIOKAWA, Zenyu
  • OKAWA, Tomohiro
  • SHIBUYA, Akito
  • MACCOSS, Malcolm
Agents
  • PINO, Mark, J.
  • JACQUES, Rui
  • BUCK, Todd, B.
  • MICHELLE, Holmes-son
  • FORREST IV, John, B.
Priority Data
62/735,89725.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMINOPYRIMIDINE COMPOUND
(FR) COMPOSÉ D'AMINOPYRIMIDINE
Abstract
(EN)
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
(FR)
La présente invention concerne un composé ayant une action inhibitrice de CaMKII, qui est supposé être utile en tant qu'agent pour la prophylaxie ou le traitement de maladies cardiaques (en particulier la tachycardie ventriculaire polymorphe catécholaminergique, la fibrillation auriculaire postopératoire, l'insuffisance cardiaque, l'arythmie fatale) et analogues. La présente invention concerne un composé représenté par la formule (I) : dans laquelle chaque symbole est tel que défini dans la description, ou un sel dudit composé.
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