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1. WO2020068827 - MICROBIAL COMPOSITIONS AND METHODS OF USE

Publication Number WO/2020/068827
Publication Date 02.04.2020
International Application No. PCT/US2019/052694
International Filing Date 24.09.2019
IPC
A61K 35/741 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
A61K 35/742 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
A61K 35/745 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
CPC
A61K 35/741
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
A61K 35/742
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
742Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
A61K 35/745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
A61K 9/4858
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4858Organic compounds
A61K 9/4891
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4891Coated capsules; Multilayered drug free capsule shells
Applicants
  • PENDULUM THERAPEUTICS, INC. [US]/[US]
Inventors
  • EID, John S.
  • CUTCLIFEE, Colleen
  • KOLTERMAN, Orville
  • PERRAUDEAU, Fanny
  • BULLARD, James
  • MCMURDIE, Paul
  • CHENG, Andrew
  • SCHICKLBERGER, Marcus
  • JUSTICE, Nicholas
Agents
  • WILLIAMSON, David
Priority Data
62/735,74724.09.2018US
62/801,98306.02.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MICROBIAL COMPOSITIONS AND METHODS OF USE
(FR) COMPOSITIONS MICROBIENNES ET MÉTHODES D'UTILISATION
Abstract
(EN)
Administering a composition comprising at least one mucin-regulating and at least one butyrate-producing microbe can provide a therapeutic effect for subjects having prediabetes or type 2 diabetes. Therapeutic effects can include a reduction in hemoglobin A1C levels, a reduction in glucose area under the curve after a meal tolerance test, or a reduction in the fasting glucose level.
(FR)
La présente invention concerne l'administration d'une composition comprenant au moins un microbe régulant les mucines et au moins un microbe produisant du butyrate pouvant produire un effet thérapeutique chez le patient atteint d'un état prédiabétique ou d'un diabète de type 2. Les effets thérapeutiques peuvent comprendre une baisse des taux de l'hémoglobine A1C, une diminution de la surface sous la courbe de la glycémie après un test de tolérance à l'ingestion d'aliments, ou une baisse de la glycémie à jeun.
Latest bibliographic data on file with the International Bureau