Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020068816 - CULTURE OF TUMOR INFILTRATING LYMPHOCYTES FROM TUMOR DIGEST

Publication Number WO/2020/068816
Publication Date 02.04.2020
International Application No. PCT/US2019/052681
International Filing Date 24.09.2019
IPC
A61K 35/17 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
C12N 5/09 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09Tumour cells
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C12N 5/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
Applicants
  • H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US]/[US]
  • MULLINAX, John Ellis [US]/[US]
  • PILON-THOMAS, Shari [US]/[US]
  • SARNAIK, Amod [US]/[US]
Inventors
  • MULLINAX, John Ellis
  • PILON-THOMAS, Shari
  • SARNAIK, Amod
Agents
  • LANIER, J. Gibson
  • HALL, Miles E.
Priority Data
62/735,45124.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CULTURE OF TUMOR INFILTRATING LYMPHOCYTES FROM TUMOR DIGEST
(FR) CULTURE DE LYMPHOCYTES INFILTRANT LES TUMEURS ISSUS D'UNE DIGESTION DE TUMEUR
Abstract
(EN)
Tumor infiltrating lymphocytes (TILs) are immune cells that have left the bloodstream and migrated into a tumor. TILs have been used in autologous adoptive transfer therapy for the treatment of cancer. Disclosed are methods for rapidly expanding tumor infiltrating lymphocytes using digested tumor cells.
(FR)
Les lymphocytes infiltrant les tumeurs (TIL) sont des cellules immunitaires qui ont quitté la circulation sanguine et migré dans une tumeur. Les TIL ont été utilisés en thérapie de transfert adoptif autoplastique pour le traitement du cancer. L'invention concerne des méthodes permettant une expansion rapide des lymphocytes infiltrant les tumeurs en utilisant des cellules tumorales provenant d'une digestion enzymatique.
Latest bibliographic data on file with the International Bureau