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1. WO2020068723 - METHOD OF PROVIDING SAFE ADMINISTRATION OF AN ANTI-CD154 ANTIBODY

Publication Number WO/2020/068723
Publication Date 02.04.2020
International Application No. PCT/US2019/052558
International Filing Date 24.09.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • JANSSEN BIOTECH, INC. [US]/[US]
Inventors
  • RIGBY, Mark
  • RAIBLE, Donald
  • PIANTONE, Alexa
  • LEU, Jocelyn
  • SABINS, Nina, Chi
Agents
  • SHANAHAN, Carly, A.
  • BELISARIO, Martin, G.
  • BUTLER, Dennis, J.
  • BARANIAK, Andrew, P.
  • ELIAS, Ragi, A.i.
Priority Data
62/735,52924.09.2018US
62/826,13129.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PROVIDING SAFE ADMINISTRATION OF AN ANTI-CD154 ANTIBODY
(FR) PROCÉDÉ POUR ASSURER L'ADMINISTRATION SÛRE D'UN ANTICORPS ANTI-CD154
Abstract
(EN)
Methods for clinically proven safe administration of an anti-CD 154 antibody or antigen binding fragment thereof by subcutaneous or intravenous administration are provided. Also provided are methods for clinically proven safe treatment of an autoimmune disease by subcutaneous or intravenous administration of an anti-CD 154 antibody or antigen binding fragment thereof, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and Sjögren' s Syndrome.
(FR)
L'invention concerne des procédés pour l'administration sûre cliniquement prouvée d'un anticorps anti-CD 154 ou d'un fragment de liaison à l'antigène de celui-ci par une administration sous-cutanée ou intraveineuse. L'invention concerne également des méthodes pour un traitement sûr cliniquement prouvé d'une maladie auto-immune, notamment de la polyarthrite rhumatoïde, du lupus érythémateux disséminé (SLE) et du syndrome de Sjögren, par l'administration sous-cutanée ou intraveineuse d'un anticorps anti-CD 154 ou d'un fragment de liaison à l'antigène de celui-ci.
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