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1. WO2020068280 - METHODS AND APPARATUS FOR LOW-VOLATILITY SAMPLING

Publication Number WO/2020/068280
Publication Date 02.04.2020
International Application No. PCT/US2019/045661
International Filing Date 08.08.2019
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/055 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
05Measuring for diagnosis by means of electric currents or magnetic fields
055involving electronic or nuclear magnetic resonance, e.g. magnetic resonance imaging
G01R 33/485 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
483with selection of signal or spectra from particular regions of the volume, e.g. in vivo spectroscopy
485based on chemical shift information
CPC
A61B 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; ; Measuring using microwaves or radiowaves
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/485
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
48NMR imaging systems
483with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
485based on chemical shift information ; CSI or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
Applicants
  • BRIGHTSPEC, INC. [US]/[US]
  • NEILL, Justin, L. [US]/[US] (US)
  • MUCKLE, Matt [US]/[US] (US)
  • REYNOLDS, Roger [US]/[US] (US)
Inventors
  • NEILL, Justin, L.
  • MUCKLE, Matt
  • REYNOLDS, Roger
Agents
  • COLICE, Christopher, Max
  • TEJA, JR., Joseph
  • TONG, Jonathan
Priority Data
62/715,84608.08.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND APPARATUS FOR LOW-VOLATILITY SAMPLING
(FR) PROCÉDÉS ET APPAREIL D'ÉCHANTILLONNAGE À FAIBLE VOLATILITÉ
Abstract
(EN)
Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation.
(FR)
La spectroscopie par résonance de rotation moléculaire (MRR) est une technique de spectroscopie à haute résolution structuralement spécifique qui peut fournir des données de processus réactionnels précises avec une résolution temporelle plus fine que pour les techniques existantes. C'est la seule technique analytique qui peut permettre d'effectuer des mesures de compositions chirales en ligne. Ceci la rend particulièrement utile pour la surveillance de réactions en ligne, qui se fait aujourd'hui en tirant manuellement des échantillons et en mesurant les échantillons hors ligne, ce qui demande 3 à 4 heures par mesure. Inversement, un spectromètre MRR peut résoudre des isomères en laps de temps d'environ 10 minutes lorsqu'il utilise une interface d'échantillonnage à faible volatilité qui est directement connectée à la ligne réactionnelle. L'interface d'échantillonnage mesure un échantillon précis de la solution réactionnelle, retire par ébullition le solvant pour concentrer l'analyte, fait se volatiliser l'analyte, et injecte l'analyte volatilisé dans la chambre de mesure du spectromètre MRR en vue d'une mesure MRR. La concentration et la volatilisation de l'échantillon se produisent rapidement et sans préparation d'échantillon supplémentaire.
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