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1. WO2020068015 - WATER-SOLUBLE, NON-AGGREGATED SILICON PHTALGCYANINE COMPOUND HAVING IN VITRO ANTICANCER EFFECT AGAINST CANCER TYPES OF LUNG, LIVER, BREST AND MELANOMA

Publication Number WO/2020/068015
Publication Date 02.04.2020
International Application No. PCT/TR2019/050566
International Filing Date 11.07.2019
IPC
C07F 7/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7Compounds containing elements of Groups 4 or 14 of the Periodic System
02Silicon compounds
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/695 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
695Silicon compounds
A61K 41/00 2020.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
CPC
A61K 41/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07F 7/025
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7Compounds containing elements of Groups 4 or 14 of the Periodic System
02Silicon compounds
025without C-silicon linkages
Applicants
  • KARADENIZ TEKNIK UNIVERSITESI [TR]/[TR]
Inventors
  • BIYIKLIOGLU, Zekeriya
  • OZEL, Arzu
  • BARUT, Burak
  • BAS, Huseyin
Agents
  • SEVINC, Cenk
Priority Data
2018/1401026.09.2018TR
2018/1401226.09.2018TR
Publication Language English (EN)
Filing Language Turkish (TR)
Designated States
Title
(EN) WATER-SOLUBLE, NON-AGGREGATED SILICON PHTALGCYANINE COMPOUND HAVING IN VITRO ANTICANCER EFFECT AGAINST CANCER TYPES OF LUNG, LIVER, BREST AND MELANOMA
(FR) COMPOSÉ DE PHTALOCYANINE DE SILICIUM NON-AGRÉGÉ SOLUBLE DANS L'EAU AYANT UN EFFET ANTICANCÉREUX IN VITRO CONTRE LES CANCERS DU POUMON, DU FOIE, DU SEIN ET LE MÉLANOME
Abstract
(EN)
The present invention relates to silicon phthalocyanine compounds and synthesis method of these compounds, which constitute an activity in cancer cells resistant to compounds having metal and whose effect spectrum is wider compared to metalliferous compounds and whose toxic effect is lower compared metalliferous compounds and whose side effects are reduced and which can be used as potential antitumor drug and which comprise anticancer and antioxidant effects and which have groups of (3,5-bis{3-[3-(diethylamino)phenoxy]propoxy}phenyl)methoxy or (3,5-bis{3-[3- (dimethylamino)phenoxy]propoxy}phenyl)methoxy.
(FR)
La présente invention concerne des composés de phtalocyanine de silicium et un procédé de synthèse de ces composés, qui présentent une activité dans les cellules cancéreuses résistantes aux composés comportant un métal et dont le spectre d'effet est plus large que celui des composés métallifères, tandis que leur effet toxique est inférieur à celui des composés métallifères, dont les effets secondaires sont réduits, qui peuvent être utilisés en tant que médicament antitumoral potentiel, qui présentent des effets anticancéreux et antioxydants et qui comportent des groupes (3,5-bis{3-[3-(diéthylamino)phénoxy] propoxy}phényl)méthoxy ou (3,5-bis{3-[3-(diméthylamino)phénoxy]propoxy}phényl)méthoxy.
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